Evaluation of Tissue and Circulating microRNA Profiles in Patients With Hepatocellular Carcinoma Subjected to Thermal Ablation

Recruiting now

Conditions studied: Hepatocarcinoma

In brief

The main objectives of this research project concern the identification of microRNAs circulating and of serum metabolites predictive of treatment response in patients with early stage hepatocellular carcinoma undergoing locoregional treatment with thermoablation. In addition, the molecular mechanisms involved in reprogramming will be identified metabolic via bioinformatics analysis and pretreatment liver biopsy analysis and analysis of screening on patient-derived primary lines for personalized therapy.

Key facts

Study ID

NCT07601464

Run by

IRCCS Azienda Ospedaliero-Universitaria di Bologna

People needed

150

Starts

2026-03-26

Expected to finish

2028-12-31

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18
• Diagnosis of hepatocarcinoma confirmed by radiology (LIRADS criteria/triphasic diagnostics) or by biopsy.
• Indication for thermoablation treatment (for radiofrequency) based on the judgment of the hepatologist/surgeon.
• Informed consent signed by the patient.

You may not qualify if…

• Presence of metastatic liver lesions of other origins.
• History of liver transplant.
• Severe, uncorrectable coagulopathy, contraindicating liver biopsy (where necessary) or ablative procedure.
• Patient refusal to participate in the study or inability to obtain informed consent.
• Pregnant women.

Where it is running

• IRCCS Policlinico di Sant'Orsola — Bologna, Emilia-Romagna, Italy (enrolling)

Full record on ClinicalTrials.gov

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