Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery
Starting soon · Not applicable
Conditions studied: Sepsis, Lung Injury
In brief
This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery. The primary goal is to determine if the choice of anesthetic technique influences the incidence or severity of this complication. Participants will be randomly assigned to one of the two anesthetic regimens during surgery. They will receive daily in-hospital assessments for lung injury and other outcomes and will be followed for clinical outcomes until 90 days after the procedure.
Key facts
- Study ID
- NCT07601256
- Run by
- Sixth Affiliated Hospital, Sun Yat-sen University
- People needed
- 480
- Starts
- 2026-08-15
- Expected to finish
- 2030-12-30
- Last updated by the study team
- 2026-05-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years.
- Diagnosis of sepsis according to Sepsis-3.0 (highly suspected or confirmed infection with acute increase in SOFA score ≥ 2).
- Scheduled to undergo surgery under general aaesthesia for source control or sepsis-related operative management.
You may not qualify if…
- Already intubated prior to entering the operating room.
- Chronic home ventilator dependence (e.g., severe chronic obstructive pulmonary disease) before surgery.
- Personal or family history of malignant hyperthermia.
- Known allergy to ciprofol or sevoflurane.
- Known allergy to egg or soy products.
- Any contraindication to the planned anaesthetic agents.
- Pregnant women.
Where it is running
- The Sixth Affiliated Hospital of Sun Yat-sen University — Guangzhou, Guangdong, China
Full record on ClinicalTrials.gov
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