A Trial of HRS-7058 in Advanced or Metastatic Non-Small Cell Lung Cancer Patients Who Have Failed Standard Treatment

Starting soon · Phase 3

Conditions studied: KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer Patients Who Have Failed Standard Treatment

In brief

The study is being conducted to evaluate the efficacy, and safety of HRS-7058 in KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer Patients Who Have Failed Standard Treatment

Key facts

Study ID

NCT07601048

Run by

Shandong Suncadia Medicine Co., Ltd.

People needed

450

Starts

2026-06-01

Expected to finish

2029-05-01

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years old to 75 years old ( including both ends ), regardless of gender ;
• Subjects with histologically or cytologically confirmed locally advanced or metastatic non-small cell lung cancer ;
• Histological specimens confirmed the presence of KRAS G12 C mutation ;
• Participants who have failed at least one line of systemic anti-tumor treatment in the locally advanced or metastatic stage. Previous systemic anti-tumor treatment should include : platinum-containing double-agent chemotherapy and immune checkpoint inhibitor therapy ( synchronous or sequential, except that the researchers determine that it is not suitable for immune checkpoint inhibitors or chemotherapy ) ;
• At least one measurable lesion conforming to the definition of RECIST v1.1 standard ;
• ECOG physical score 0-1 points ;
• Expected survival time ≥ 12 weeks ;
• Have adequate bone marrow and organ function
• Subjects were required to give informed consent to this study before the trial and voluntarily sign a written informed consent form.

You may not qualify if…

• Subjects with active central nervous system ( CNS ) metastasis ;
• Other malignant tumors occurred within 5 years before the first administration, except for fully treated cervical carcinoma in situ, basal cell or squamous cell skin cancer, local prostate cancer after radical resection, ductal carcinoma in situ after radical resection, and papillary thyroid carcinoma after radical resection.
• Having undergone major surgery or significant trauma within 4 weeks prior to the first use of the study drug ;
• Subjects with a history of interstitial pneumonia or suspected interstitial pneumonia by imaging examination during screening ; or other lung diseases that seriously affect lung function ;
• Have serious cardiovascular and cerebrovascular diseases
• Severe infection occurred within 4 weeks before the first administration.
• The first study of arterial / venous thrombosis events within 3 months before medication was conducted.
• Have a history of immunodeficiency, including HIV test positive ;
• There is active hepatitis B or hepatitis C ;
• Subjects with active central nervous system ( CNS ) metastasis ;

Where it is running

• Tianjin Medical University Cancer Institute and Hospital — Tianjin, Tianjin Municipality, China

Full record on ClinicalTrials.gov

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