Periodontal Disease in Patients With Lynch Syndrome
Starting soon
Conditions studied: Lynch Syndrome, Periodontal Disease
In brief
The field of human microbiome research has undergone a revolution in its approach toward understanding how microorganisms influence the physiology of their host 1. The influence of the oral microbiota is not confined to this location 2. Periodontitis is a "chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by a progressive destruction of the tooth supporting apparatus"3. Given these observations, the central research question of the present study is to determine the prevalence of periodontitis in patients with Lynch syndrome (LS) compared with reference prevalence estimates from the general population40.
Key facts
- Study ID
- NCT07600710
- Run by
- Rotundo Roberto
- People needed
- 25
- Starts
- 2026-06-01
- Expected to finish
- 2026-07-31
- Last updated by the study team
- 2026-05-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years;
- All sexes eligible
- Established diagnosis of LS performed as part of clinical practice, with a germline pathogenic/likely pathogenic variant in one of the following genes: MLH1, MSH2, MSH6, PMS2, and EpCAM
- LS subjects undergoing surveillance gastrointestinal endoscopy according to clinical practice and international guidelines.
- Subjects underwent dental and periodontal examination
You may not qualify if…
- Age < 18 years;
- Absence of sufficient periodontal clinical or radiographic data to establish a periodontal diagnosis;
- Subjects affected by systemic, autoimmune, chronic inflammatory, neurological, or severe psychiatric disorders, or by any other clinical condition that may interfere with study participation or data interpretation
- Subjects with systemic conditions known to strongly affect periodontal status (e.g. uncontrolled diabetes, autoimmune inflammatory diseases, ongoing cancer therapy) were excluded to reduce major confounding factors that could independently alter periodontal outcomes.
Where it is running
- IRCCS San Raffaele — Milan, Italy
Full record on ClinicalTrials.gov
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