Evaluation of Persistent Infection by Oncogenic Human Papillomavirus (HPV) in Patients Treated for Cervical Carcinoma and Its Relation to Prognostic Factors

Starting soon

Conditions studied: Locally Advanced Cervical Cancer, Prognostic Biomarker

In brief

Cervical cancer is strongly associated with HPV infection, yet current post-treatment follow-up relies on cytology and imaging, which have limited accuracy, particularly after radiotherapy. Emerging evidence suggests that HPV clearance is linked to better outcomes and that HPV testing may outperform cytology in detecting recurrence. This study aims to evaluate a panel of prognostic biomarkers to identify patients at higher risk of recurrence. These include cervical and circulating HPV-DNA (presence, genotype, and load), vaginal microbiota, host DNA methylation, SOD2 expression, and immune profile. By enabling earlier and more accurate detection of recurrence, these biomarkers may improve patient outcomes, reduce reliance on costly imaging, and support earlier discharge for low-risk patients.

Key facts

Study ID

NCT07600515

Run by

Instituto do Cancer do Estado de São Paulo

People needed

100

Starts

2026-05-10

Expected to finish

2030-05-10

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of HPV-associated squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma
• Treatment-naïve
• FIGO 2018 stage IB3 to IVA
• Candidates for curative-intent pelvic radiotherapy with concurrent chemoradiation

You may not qualify if…

• Tumors with rare histology, such as small cell tumors, sarcomas, and lymphomas
• FIGO 2018 stages IA, IB1, IB2, and IVB
• Planned initial treatment is surgical or palliative
• Uncertain primary tumor site (cervix vs. endometrium)
• Pregnant or in the postpartum period
• Immunosuppression (e.g., HIV infection with active disease, autoimmune diseases, transplant recipients)

Full record on ClinicalTrials.gov

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