A Phase 2b Study of the Effects of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Atopic Dermatitis, Atopic, Dermatitis, Dermatitis, Atopic, Dermatologic Disease, Eczema, Eczema Atopic Dermatitis, Eczema, Atopic

In brief

This is a phase 2b, multicenter, randomized, double-blind, placebo-controlled study.

Key facts

Study ID

NCT07599813

Run by

Apollo Therapeutics Ltd

People needed

280

Starts

2026-05-28

Expected to finish

2028-04-30

Last updated by the study team

2026-06-02

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-65 inclusive, at the time of signing the informed consent.
• Chronic AD for at least 1 year based on clinically confirmed diagnosis of active AD, according to Hanfin and Rajka criteria.
• Participants with moderate-to-severe AD defined by:
• Investigator global assessment (IGA) score of ≥ 3 (on a scale of 0 to 4, in which three is moderate and four is severe) at Screening and Baseline.
• AD involvement of ≥ 10% body surface area (BSA) at Screening and Baseline.
• EASI score of ≥ 16 at Screening and at Baseline.
• Peak pruritus numerical rating scale (PP-NRS) ≥ 4 at Baseline. Note: The PP-NRS will be calculated from the 7 consecutive days immediately preceding Baseline. A minimum of 4 daily scores out of the 7 days is needed.
• Participants who are candidates for systemic therapy, defined as history of inadequate response to topical AD treatments applied for at least 28 days, or for the maximum duration recommended by the product prescribing information, or for treatment with topical AD treatments is medically inadvisable due to important side effects or safety risks.
• Contraceptive use should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
• Participant provides signed informed consent

You may not qualify if…

• History or other evidence of severe illness or any other conditions such as psychiatric illness, severe depression or previous history of suicidal attempt in past 10 years that would render the participant, in the opinion of the Investigator, unsuitable for the study.
• Active, chronic or acute infection requiring systemic antibiotics, antivirals, antiparasitics, antiprotozoals, or antifungals within 2 weeks before the Baseline.
• Participant has a current diagnosis of other active skin disease (e.g., psoriasis or lupus erythematosus) or skin infection (bacterial, fungal, or viral) that may affect the evaluation of AD or would interfere with the study assessments based on the Investigator's judgement.
• Participant has history of significant flares of AD within 4 weeks prior to screening, in the opinion of the investigator.
• Participant has a severe comorbidity that may require systemic steroids therapy or other interventions or requires active frequent monitoring (e.g., unstable chronic asthma) based on investigator judgement.
• Any clinically significant abnormalities in rhythm, conduction or morphology of the resting electrocardiogram (ECG) and any clinically significant abnormalities in the 12-lead ECG as considered by the Investigator that may interfere with the interpretation of QTc interval changes.
• Participant has severe and uncontrolled seasonal or allergic rhinitis, severe and uncontrolled asthma or any other severe and uncontrolled atopic disease as judged by the Investigator.
• Treatment of AD with medicated moisturizers available only by prescription within 2 weeks prior to the Baseline visit.
• Active human immunodeficiency virus (HIV): confirmed positive anti-HIV antibody (HIV Ab) test.
• Active hepatitis B virus (HBV): hepatitis B surface antigen (HBs Ag) positive (+) or hepatitis B core antibody (HBc Ab) positive (+) confirmed by HBV PCR positive (+).
• Active hepatitis C virus (HCV): If hepatitis C antibody positive (+), confirmed by HCV RNA test. Note: a participant with documented proof of cure from HCV may be enrolled.
• Evidence of active or latent tuberculosis.
• Receipt of live or attenuated live vaccine within 6 weeks prior to screening.
• Participant had a major surgery within 8 weeks prior to Baseline or has a major surgery planned during the study.
• Participant is known to have immune deficiency or is immunocompromised
• Diagnosed with a malignancy within 5 years of enrollment (suspected malignancy should be ruled out by blood or tissue biopsy, as applicable) with the exception of:
• Completely resected basal cell or squamous cell carcinoma of the skin.
• Carcinoma in situ of the cervix.
• Has had previous exposure to anti-IL-18 therapy.
• Known allergy/sensitivity to any component of IMP.
• History of use of any of these medications as follows:
• Dupilumab, tralokinumab, lebrikizumab, nemolizumab within 8 weeks prior to Baseline.
• Systemic JAKi within 4 weeks prior to Baseline.
• Any topical medicated treatment that could affect AD within 2 weeks prior to Baseline, including, but not limited to, topical corticosteroids, topical phosphodiesterase (PDE4) inhibitors, topical calcineurin inhibitors, topical JAKi, tars, antimicrobials, medical devices, and bleach baths.
• Systemic therapies (other than biologics) that could affect AD not noted above, within 4 weeks prior to Baseline, including but not limited to, retinoids, calcineurin inhibitors, methotrexate, hydroxycarbamide (hydroxyurea), azathioprine, oral/injectable corticosteroids. Note: Intranasal corticosteroids and inhaled corticosteroids are allowed. Eye and ear drops containing corticosteroids are also allowed.

Where it is running

• Integrative Skin Science and Research — Sacramento, California, United States (enrolling)
• Northridge Clinical Trials — Northridge, California, United States (enrolling)
• Centre de Recherche Saint-Louis (Sherbrooke) — Sherbrooke, Quebec, Canada (enrolling)
• Ada West Research, LLC — Meridian, Idaho, United States (enrolling)
• Sadick Research Group, LLC — New York, New York, United States (enrolling)
• Skin Cancer and Dermatology Institute — Reno, Nevada, United States (enrolling)
• ClinOhio Research Services — Columbus, Ohio, United States (enrolling)
• Progressive Clinical Research, PA — San Antonio, Texas, United States (enrolling)
• Saskatoon Dermatology Centre — Saskatoon, Saskatchewan, Canada (enrolling)
• DS Research of Southern Indiana,LLC — Clarksville, Indiana, United States (enrolling)
• Best Skin Research, LLC — Camp Hill, Pennsylvania, United States (enrolling)
• International Dermatology Research, INC — Hollywood, Florida, United States
• Dermatology Research Associates — Los Angeles, California, United States
• Quality Care Clinical Research — Miami, Florida, United States
• ABMED Clinical Research Corp. — Cape Coral, Florida, United States
• Paradigm Clinical Research Centers, LLC: Wheat Ridge — Wheat Ridge, Colorado, United States
• Metropolis Dermatology — Los Angeles, California, United States
• Saguaro Dermatology Associates — Phoenix, Arizona, United States
• Endeavor Health — Skokie, Illinois, United States
• Valiance Clinical Research - Tarzana — Tarzana, California, United States
• Elligo - Georgia Skin & Cancer Clinic (Sidney P. Smith, MD, PC) — Savannah, Georgia, United States
• Marvel Research, LLC — Huntington Beach, California, United States
• Dawes Fretzin Clinical Research Group, LLC — Columbus, Indiana, United States
• Chesapeake Clinical Research, Inc — Pasadena, Maryland, United States
• NMC Research LLC — Tampa, Florida, United States

Full record on ClinicalTrials.gov

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