Nutritional Supplementation to Improve Colorectal Cancer Surgery

Starting soon · Not applicable

Conditions studied: Colorectal Cancer, Colorectal Surgery

In brief

This study aims to explore the effectiveness of perioperative Oral Nutritional Supplementation (ONS) combined with an optimized, tailored diet in reducing the risk of postoperative complications and improving the nutritional status of colorectal cancer patients scheduled for curative colorectal resection.

Key facts

Study ID

NCT07599501

Run by

Istituto Clinico Humanitas

People needed

190

Starts

2026-09-30

Expected to finish

2028-02-28

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants aged more than 18 years old.
• Histological diagnosis of colorectal adenocarcinoma.
• Participants scheduled for elective minimally invasive colorectal resection.
• Participants with a preoperative MUST score equal to or below 2. Exclusion criteria
• Any condition that, in the opinion of the investigator, may interfere with the study procedures.
• Emergent surgery.
• Planned open surgery. Participants undergoing unplanned surgical conversion (from minimally invasive to open) will be withdrawn from the study.
• Any concomitant surgery unrelated to the primitive colorectal cancer (for example, concomitant liver metastasis resection).
• Participants with preoperative MUST score > 2.
• Pregnant or breastfeeding participants. Women of childbearing potential must agree to use a reliable contraceptive method. Otherwise, a pregnancy urine test must be performed at each study visit to exclude a potential pregnancy.

Where it is running

• IRCCS Humanitas Research Hospital — Rozzano, Milano, Italy

Full record on ClinicalTrials.gov

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