Evaluation of the Changes in Matrix Metalloproteinase-9 Levels With Salvadora Persica (Miswak) in Periodontal Fibroblasts and Gingival Crevicular Fluid in Patients With Periodontitis

Starting soon · Early Phase 1

Conditions studied: Stage II or Stage III Grade B Periodontitis

In brief

The study is conducted to evaluate the invitro effect of Salvadora persica (miswak) extract on periodontal fibroblasts production of matrix metalloproteinase-9 (MMP-9) and prostaglandin E2 (PGE2) and correlating the results to clinical outcomes and biomarkers by assessing the MMP-9 and PGE2 levels in gingival crevicular fluid by a randomized controlled clinical trial comparing the use of toothbrush as the control group with miswak chewing stick as a substitute to personal mechanical plaque control in patients with stage II or III grade B periodontitis.

Key facts

Study ID

NCT07599397

Run by

Cairo University

People needed

24

Starts

2026-06-01

Expected to finish

2026-12-01

Last updated by the study team

2026-05-20

Who can join

Age: 20 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Stage II or III, grade B periodontitis

You may not qualify if…

• Have poor manual dexterity
• Systemic condition that may affect healing
• Administration of certain medications that may modify the outcomes
• Smoking patients
• Pregnant females
• Periapical involvement in teeth
• Habitual or experienced users of miswak chewing sticks
• History of topical or systemic chemical plaque control during the past 6 months
• History of periodontal surgery during the past 6 months
• Local risk factor that interfere with accessibility for regular personal plaque control aids

Where it is running

• Ahram Canadian University — Giza, Egypt

Full record on ClinicalTrials.gov

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