BETA: Study in Prediabetes Type 2 Diabetes

Enrolling by invitation

Conditions studied: Prediabetes, Type 2 Diabetes

In brief

This study is testing the feasibility of using non-invasive, remote digital tools including continuous glucose monitors (CGMs) and the Oura Ring to predict the function of beta-cells, the cells in the pancreas that secrete insulin. This study is being done in individuals with prediabetes or Type 2 diabetes. The aim is to develop remote digital tools that can predict the health and functioning of the pancreas in people with prediabetes or Type 2 diabetes, allowing personalized treatment approaches to preserve insulin secretion.

Key facts

Study ID

NCT07598773

Run by

4YouandMe

People needed

130

Starts

2026-03-25

Expected to finish

2027-02-01

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18+ years old
• Have an established diagnosis of Prediabetes or Type 2 diabetes
• Have a glycated hemoglobin (HbA1c) below 8% (64 mmol/mol) and a body mass index (BMI) between 18-40 kg/m2 that will be determined from your height and weight
• Are willing to use an Abbott FreeStyle Libre 3/3+ Continuous Glucose Monitor (CGM) supplied by the study and provide the study investigators access to the CGM data
• Are willing to use the study wearable devices (e.g., Oura Ring)
• Are able to read, write, and speak in English
• If you use long-acting insulin, you must be on a prescribed regimen where you administer it at bedtime only and no other time of day (bolus short-acting may be used at any time as needed)
• All medication regimens must have a minimum of 30 days supply, and no new medications started within 30 days of enrollment
• Weight must be stable (± 10 pounds) for 2 months prior to enrollment
• Must have a personally owned iPhone 6s or newer (iOS 16.4+) or Android smartphone (version 12 or newer) and use this phone to download and use the study app and use the provided study devices
• Must have a personally owned computer or tablet or have access to these devices at home
• Must reside in the North San Francisco Bay area and be willing to travel to Novato, CA to attend two morning clinic assessments at the Buck Institute

You may not qualify if…

• Using any Abbott CGM (prescribed or OTC)
• BMI <18 kg/m2 or >40 kg/m2
• Dairy or soy allergy
• Currently pregnant or breastfeeding
• Diagnosed with Type 1 diabetes or MODY (Maturity-Onset Diabetes of the Young)
• Using an insulin pump
• Using any of the following medications: Glucocorticoids, Non-Selective Beta Blockers (e.g., propranolol), Thiazide Diuretics
• Currently using tobacco products (cigarettes, vapes, chew, dip, etc.)
• Hospitalized overnight for any reason in the last 3 months
• History of pancreatic disease (other than diabetes) or pancreatic transplantation
• Have any active malignancy within the last 12 months
• History of bariatric / other gastrointestinal surgery anticipated to affect glucose metabolism / cause gastroparesis
• History of systemic disease (hepatic, cardiovascular, other) likely to interfere with glucose metabolism or study participation

Where it is running

• Buck Institute for Research on Aging — San Francisco, California, United States

Full record on ClinicalTrials.gov

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