Trajectory-Based Phenotyping After Coronary Artery Bypass Surgery

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Conditions studied: Coronary Artery Bypass Grafting, Postoperative Acute Kidney Injury, Postoperative Complications, Risk Stratification

In brief

Coronary artery bypass grafting is a commonly performed heart surgery, but patients may have different risks for postoperative complications even when their preoperative risk scores are similar. EuroSCORE II is widely used to estimate surgical risk before cardiac surgery, but it may not fully reflect how the body responds during the early postoperative period. This retrospective observational study will evaluate adult patients who underwent elective coronary artery bypass grafting with cardiopulmonary bypass between January 1, 2022 and December 31, 2025. The study will use existing hospital records and laboratory data. No additional treatment, test, or intervention will be given to patients as part of this study. The main aim is to examine whether early postoperative changes in inflammatory and renal laboratory markers can identify different patient subgroups, called phenotypes. These markers include neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, triglyceride-glucose index, and serum creatinine. The study will evaluate whether these phenotype groups are associated with postoperative acute kidney injury and prolonged intensive care unit stay. The study will also assess whether this early postoperative phenotype-based classification provides additional risk information beyond EuroSCORE II.

Key facts

Study ID

NCT07598682

Run by

Bursa Sevket Yilmaz Training and Research Hospital

People needed

1000

Starts

2026-05-07

Expected to finish

2026-07-01

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients aged 18 years or older
• Patients who underwent elective on-pump coronary artery bypass grafting
• Patients operated between January 1, 2022 and December 31, 2025
• Patients with available perioperative clinical and laboratory data required for analysis

You may not qualify if…

• Patients undergoing emergency surgery
• Patients undergoing concomitant valve surgery
• Patients with missing or inconsistent key clinical or laboratory data

Where it is running

• University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital — Bursa, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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