Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty

Recruiting now

Conditions studied: Postoperative Cognitive Dysfunction (POCD), Cognitive Change, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty

In brief

The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery. The main question it aims to answer is: Does patients experience cognitive changes in cognitive test performance from before surgery to the first day after surgery? Participants will: * Complete a cognitive test battery virtually about 14 days before surgery, and on the first and seventh day after their operation. * Record pain levels and pain medicine use during the first week after surgery

Key facts

Study ID: NCT07598552
Run by: Odense University Hospital
People needed: 48
Starts: 2026-05-18
Expected to finish: 2026-11-30
Last updated by the study team: 2026-06-22

Who can join

Age: 70 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Unilateral elective primary Total Hip Arthroplasty, Total Knee Arthroplasty, or Unicompartmental Knee
Native Danish speaker
Spinal anesthesia

You may not qualify if…

Inability or unwillingness to provide informed consent
Inability to comply with virtual study procedures or follow-up sessions, including because of visual or hearing impairment
Known dementia or other diagnosed cognitive disorders or Brief Assessment of Impaired Cognition (BASIC)≤20
Parkinson's disease or other neurological conditions causing functional impairment
History of alcohol abuse (≥35 units per week)
Daily use of anxiolytics or hypnotics
Not discharged on the day of surgery

Where it is running

Odense University Hospital, Svendborg Hospital — Svendborg, Denmark (enrolling)

Full record on ClinicalTrials.gov

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