Salvaged Red Blood Cell Transfusion During Pancreatic Adenocarcinoma Operations

Starting soon · Not applicable

Conditions studied: Pancreatic Surgery

In brief

The purpose of this study is to prospectively study the safety of salvage red blood cell (sRBC) transfusion during pancreatic surgery. Primary Objective: 1. To summarize rates and timing of septic adverse events (AE) for patients who receive sRBC or aRBC transfusions within 72 hours of peri-operative transfusion. 2. To summarize rates and timing of transfusion related AEs for patients who receive sRBC or aRBC transfusions within 72 hours of peri-operative transfusion. 3. To summarize rates and timing of AEs in the first 7 post-operative days. Secondary Objectives: 1. To summarize the number of units of aRBC transfused post operative day (POD) #0 after sRBC transfusion in the operating room. 2. To summarize the number of units of aRBC transfused POD#1-7 after sRBC transfusion the operating room, in the absence of overt post-operative hemorrhage.

Key facts

Study ID

NCT07598357

Run by

NYU Langone Health

People needed

40

Starts

2026-06-01

Expected to finish

2031-06-01

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provision of signed and dated informed consent form. Able to understand their disease and the exploratory nature of sRBC transfusion during surgery for this histology.
• Patient is 18 years of age or older
• Patient has a diagnosis of cytologically or pathologically confirmed pancreatic adenocarcinoma
• Patient has an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
• Patient has an American Society of Anesthesiologists (ASA) classification of physical health status of 1-4
• Life expectancy of greater than six months
• Hemoglobin > 8.9 g/dl
• Platelet count greater than 200,000/mm3
• International Normalization Ratio ≤1.8
• Total serum bilirubin ≤ 2 mg/dL
• Serum creatinine ≤ 1.5 mg/dl
• Recovered from any hematologic toxicity less than grade 3 from all prior chemotherapy or radiotherapy, and be at least 14 days past the date of their last treatment.

You may not qualify if…

• Concomitant medical problems that would place the patient at unacceptable risk for a major surgical procedure.
• History of congestive heart failure and/or an LVEF <40%.
• Metastases
• Active systemic infections, hematological diseases, coagulation disorders or other major medical illnesses of the cardiovascular, hepatic, renal, respiratory or immune system.
• Patients with transabdominal drains, or peripancreatic abscess or fluid collections on cross-sectional imaging.

Where it is running

• NYU Langone Health — New York, New York, United States

Full record on ClinicalTrials.gov

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