Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Therapy in Smokers

Starting soon · Not applicable

Conditions studied: Hyaluronic Acid, Periodontal Therapy, Oral Microbiota, Oxidative Stress, Metallothionein, 8-OHdG, Periodontitis

In brief

The goal of this clinical trial is to evaluate whether hyaluronic acid (HA) improves periodontal healing in people with periodontal disease who smoke. Moreover, the effects of HA on biomolecules and bacteria levels will be assessed during the follow up period. The main questions it will answer are: Will periodontal sites treated with HA gel after non-surgical periodontal treatment (NSPT) lead to better outcomes in clinical parameters compared to the sites treated with NSPT only in smokers? Will adjunctive use of HA gel reduce oxidative stress markers and bacteria levels during follow-up? Researchers will compare periodontal sites receiving NSPT with adjunctive HA gel application to sites receiving NSPT alone to determine whether HA provides additional clinical, biochemical and microbiological benefits. Participants will: * first receive full-mouth NSPT then, randomization will be performed in selected jaw to determine the test sites. These two interproximal test sites will additionally receive HA gel application. * attend follow-up visits at 1, 3 and 6 months for clinical periodontal measurements and to provide gingival crevicular fluid samples (GCF) and subgingival samples. The GCF samples will be evaluated for Metallothionein (MT) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and subgingival samples for periodontal pathogens.

Key facts

Study ID

NCT07597213

Run by

Marmara University

People needed

23

Starts

2026-06-01

Expected to finish

2028-07-01

Last updated by the study team

2026-06-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals who sign the informed consent form
• Participants who are systemically healthy
• Participants who smoke (for >5 years and ≥10 cigarettes per day)
• Participants diagnosed with Stage III or Stage IV periodontitis
• Participants with at least 20 natural teeth present in the mouth (excluding third molars)
• Participants with two non-adjacent interproximal sites in each quadrant of either jaw, presenting probing depth (PD) and clinical attachment level (CAL) ≥6 mm, and with no caries, restorations, or furcation involvement

You may not qualify if…

• Individuals who do not sign the informed consent form
• Individuals having any systemic disease
• Participants who have used antibiotics within the last 3 months
• Participants who have received any periodontal treatment within 6 months prior to the study
• Participants who are pregnant or lactating

Where it is running

• Department of Periodontology, Faculty of Dentistry, Marmara University — Istanbul, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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