A Clinical Study of Cizutamig in Thyroid Eye Disease

Recruiting now · Phase 1

Conditions studied: Thyroid Eye Disease, TED

In brief

The purpose of this study is to evaluate the safety, tolerability, PK, PD, immunogenicity, and preliminary clinical activity of cizutamig in patients with thyroid eye disease (TED).

Key facts

Study ID

NCT07597200

Run by

Candid Therapeutics

People needed

38

Starts

2026-05-08

Expected to finish

2028-06-30

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-75 years old at the time of signing the Informed Consent Form
• Diagnosis of Graves' Disease with active, moderate to severe TED in accordance with the Chinese Guidelines for the Diagnosis and Treatment of Thyroid-Associated Ophthalmology (2022) at Screening and Day 1

You may not qualify if…

• Inadequate clinical laboratory parameters at Screening
• Active infection present
• Receipt of, or inability to discontinue, any of the excluded therapies
• History of progressive multifocal leukoencephalopathy
• History of primary immunodeficiency
• Central nervous system disorders that the investigator considers would increase risk to the subject
• Investigator-determined significant comorbidity(ies)
• Have a diagnosis or history of malignant disease within 5 years prior to Screening
• Active tuberculosis or lack of documentation of completed treatment for active pulmonary tuberculosis
• History of severe allergic or anaphylactic reactions to mAb therapy (or recombinant antibody-related fusion proteins) or any constituents of cizutamig
• Pregnant or breastfeeding women
• Patients who do not agree to use highly effective contraception as specified in the protocol

Where it is running

• Shanghai Ninth People's hospital Shanghai Jiaotong University school of medicines — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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