MIRNA QUANTIFICATION IN PATIENTS WITH SEPTIC SHOCK
Recruiting now
Conditions studied: Sepsis and Septic Shock
In brief
Sepsis-induced immunosuppression (SIS) is a common complication in patients with septic shock. Reduced expression of Human leukocyte antigen isotype DR (HLA-DR) on circulating monocytes is a marker for SIS and correlates with risk of secondary infections and mortality. The miRSep study aims to improve the understanding of early microRNA (miRNA) mediated changes in HLA-DR on monocytes in patients with septic shock.
Key facts
- Study ID
- NCT07597122
- Run by
- Insel Gruppe AG, University Hospital Bern
- People needed
- 56
- Starts
- 2026-06-01
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-06-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Septic shock:
- New onset (<24h) of septic shock diagnosis according to Sepsis-3 definition
- (suspected) infection
- Vasopressors required to maintain mean arterial pressure ≥65mm Hg (despite adequate fluid resuscitation)
- Serum lactate level > 2mmol/L
- Minimum age of 18 years
- Expected length of stay >48h
- Written consent from an independent physician
- Critically ill:
- Patients on mechanical ventilation (MV) in the ICU without an admission diagnosis of sepsis/septic shock according to Sepsis-3 definition
- Minimum age of 18 years
- Expected length of stay >48h
- Written consent from an independent physician
You may not qualify if…
- Age < 18 years
- Patients known not to speak German or French
- Patients with known.
- Pre-existing congenital or acquired severe immune deficiency (e.g. severe combined immunodeficiency, HIV infection, AIDS) or
- current immunosuppressive therapy (immunosuppressive biologicals or active lymphocyte therapy e.g. endoxan, rituximab or corticosteroid use at a dose > 10 mg/day equivalent of prednisone. However, acute corticosteroid treatment of a relative adrenal insufficiency using a maximum hydrocortisone dose of 200 mg/day is accepted.
Where it is running
- Inselspital — Bern, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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