Biofeedback-Assisted Pelvic Floor Rehabilitation for Radiation-Induced Sexual Dysfunction in Cervical Cancer Survivors

Recruiting now · Not applicable

Conditions studied: Cervical Cancer, Female Sexual Dysfunction (FSD), Radiation Induced Pelvic Floor Muscle Dysfunction

In brief

This randomized controlled trial aims to evaluate the efficacy of biofeedback-assisted pelvic floor muscle training on radiation-induced sexual dysfunction in cervical cancer survivors following pelvic radiotherapy. Participants will be randomly assigned to receive either biofeedback-assisted pelvic floor rehabilitation or supervised conventional pelvic floor muscle training without biofeedback for 8 weeks.

Key facts

Study ID

NCT07597083

Run by

Beni-Suef University

People needed

60

Starts

2026-05-19

Expected to finish

2027-03-31

Last updated by the study team

2026-05-20

Who can join

Age: 30 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female participants aged 30-60 years.
• Histologically confirmed diagnosis of cervical cancer (any stage at diagnosis) and completion of primary treatment.
• Completion of pelvic radiotherapy (external beam radiotherapy and/or brachytherapy) ≥3 months prior to enrollment.
• Presence of radiation-induced sexual dysfunction, defined as a Female Sexual Function Index (FSFI) score ≤26.55.
• Self-reported sexual activity within the previous 6 months.
• Medically stable with no current oncologic indication for active treatment, confirmed by treating oncologist.
• Ability to understand study procedures and provide written informed consent.

You may not qualify if…

• Evidence of recurrent, persistent, or metastatic cervical cancer.
• Participation in pelvic floor muscle training or biofeedback-based rehabilitation within the previous 6 months.
• Presence of severe pelvic organ prolapse (stage III-IV).
• Active pelvic infection, pelvic inflammatory disease, or untreated vaginal infection.
• Ongoing significant vaginal bleeding of unknown or pathological origin.
• Untreated or active urinary tract infection at the time of enrollment.
• Neurological disorders affecting pelvic floor function (e.g., spinal cord injury, multiple sclerosis).
• Severe psychiatric illness or uncontrolled mental health disorder affecting participation.
• Cognitive impairment preventing understanding of instructions or adherence to protocol.
• Current pregnancy or planning pregnancy during the study period.
• Participation in another interventional clinical or rehabilitation trial within the last 3 months or during the study period.

Where it is running

• Out patient clinic , faculty of Physical Therapy, Beni Sueif university — Banī Suwayf, Egypt (enrolling)

Full record on ClinicalTrials.gov

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