Immediate Implant Placement With Subepithelial Connective Tissue Grafting and Probiotics

Starting soon · Not applicable

Conditions studied: Dental Implant Failed

In brief

The present study aims to evaluate and compare the clinical, radiographic, and biological peri-implant tissue outcomes of platelet-rich fibrin versus probiotics as adjuncts to immediate implant placement combined with subepithelial connective tissue grafting in adults requiring single immediate implant placement.

Key facts

Study ID

NCT07596758

Run by

Kafrelsheikh University

People needed

22

Starts

2026-05-14

Expected to finish

2027-05-30

Last updated by the study team

2026-05-19

Who can join

Age: 20 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 20 to 45 years.
• Systemically healthy patients eligible for implant surgery.
• Patients requiring extraction of a single non-restorable tooth indicated for immediate implant placement.
• Implant sites located in the maxillary esthetic or para-esthetic zone.
• Sites with sufficient apical and/or palatal bone to permit correct three-dimensional implant positioning and achieve adequate primary stability.
• Sites suitable for simultaneous subepithelial connective tissue grafting.
• Patients with acceptable oral hygiene and good compliance with periodontal and implant treatment.
• Patients willing to attend all follow-up visits and comply with study instructions.

You may not qualify if…

• Medically compromised patients or patients with systemic conditions that may contraindicate implant surgery or interfere with healing.
• Smokers.
• Pregnant or lactating women.
• Patients with uncontrolled periodontal disease or poor oral hygiene.
• Patients with acute infection at the intended implant site.
• Patients with insufficient bone volume preventing immediate implant placement with adequate primary stability.
• Patients with a history of head and neck radiotherapy or chemotherapy.
• Patients receiving bisphosphonates or other medications known to affect bone metabolism or soft tissue healing.
• Patients with parafunctional habits that may jeopardize implant stability or restorative success.
• Patients unwilling or unable to complete the follow-up period.

Where it is running

• faculty of dentistry, kafrelsheikh University — Kafr ash Shaykh, Kafrelsheikh, Egypt

Full record on ClinicalTrials.gov

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