Retrospective Analysis of CPET and Cognitive Tests of Healthy Individuals, Treated With 60 Treatment of HBOT

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Conditions studied: Hyperbaric Oxygenation, Cardiorespiratory Fitness, Cognition

In brief

This retrospective observational study evaluates physiological and cognitive changes following a series of 60 hyperbaric oxygen therapy (HBOT) sessions in healthy individuals. Participants underwent treatment five days per week, each session included 90 minutes exposure to 100% oxygen at 2ATA with a five-minute air break every 20 minutes. Pre- and post-treatment data include cardiopulmonary exercise testing (CPET) and standardized cognitive assessments. The study aims to characterize associations between changes in cardiorespiratory fitness and cognitive performance following repeated HBOT exposure in a real-world clinical cohort

Key facts

Study ID

NCT07596641

Run by

Assaf-Harofeh Medical Center

People needed

1000

Starts

2026-12-01

Expected to finish

2028-03-30

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 18-65 years
• Completed a full treatment series of 60 hyperbaric oxygen therapy (HBOT) sessions at the Sagol Center
• Availability of pre- and post-treatment cardiopulmonary exercise testing (CPET) data
• Availability of pre- and post-treatment cognitive assessment data

You may not qualify if…

• Inability to complete a maximal CPET test, pre and post HBOT or Missing pre- or post-treatment CPET data.
• Incomplete HBOT treatment series
• Missing cognitive assessment data

Full record on ClinicalTrials.gov

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