Gingival Hyperpigmentation Treatment

Recruiting now · Phase 2

Conditions studied: Gingival Pigmentation, Depigmentation, Vitamin C, Glutathione

In brief

It is a clinical study conducted to evaluate the effect of vitamin C and Glucathonine injection of pigmented gingival tissue versus surgical removal by scalpel

Key facts

Study ID

NCT07595705

Run by

Cairo University

People needed

30

Starts

2025-08-01

Expected to finish

2027-10-01

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The selection criteria were done according to Gingival pigmentation index is as follows (Dummett and Bolden)10:
• Score0:absence of pigmentation
• Score1:spotsofbrowntoblackcolororpigments
• Score2:browntoblackpatchesbutnotdiffusepigmentation
• Score3:diffuse brown to black pigmentation,marginal,and attached.
• Patients who have Dummett and Bolden index score 1, 2, or 3 will be included in addition to the following criteria:
• above 18yrs
• systemically free
• physiologic gingival hyperpigmentation related to esthetic region
• well maintained oral hygiene and willing to undergo minor surgical procedures

You may not qualify if…

• systemic diseases associated with pathological hyperpigmentation or improper delayed wound healing (uncontrolled diabetes, autoimmune diseases, etc.)
• pregnant and lactating mothers
• usage of chlorhexidine or povidone iodine
• Local causes (smoking)
• periodontal diseases (plaque and non-plaque induced gingivitis or periodontitis)
• non compliant patients

Where it is running

• Faculty of Dentistry — Al Fayyum, Faiyum Governorate, Egypt (enrolling)

Full record on ClinicalTrials.gov

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