A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Obesity, Overweight and/or Obesity, Overweight

In brief

The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes. About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe. People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.

Key facts

Study ID

NCT07595549

Run by

Pfizer

People needed

954

Starts

2026-06-10

Expected to finish

2028-06-21

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged ≥18 years.
• BMI of: ≥30 kg/m2 or ≥27.0 kg/m2 to <30.0 kg/m2 and must have at least 1 of the following weight-related co-morbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or T2D.

You may not qualify if…

• Have a self-reported body weight change greater than 5% within 90 days prior to Screening.
• Diagnosis of type 1 diabetes or any other form of diabetes other than T2D.
• History of acute or chronic pancreatitis.
• Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2).

Where it is running

• Midwest Eye Center — Cincinnati, Ohio, United States (enrolling)
• Velocity Clinical Research, Mt. Auburn — Cincinnati, Ohio, United States (enrolling)
• VIP Trials — San Antonio, Texas, United States (enrolling)
• ClearVue Eye Care — Roseville, California, United States (enrolling)
• Clinical Trials Research — Sacramento, California, United States (enrolling)
• ImmuniMet, LLC — Modesto, California, United States (enrolling)
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States (enrolling)
• Nature Coast Clinical Research — Crystal River, Florida, United States (enrolling)
• West Coast Eye Institute — Lecanto, Florida, United States (enrolling)
• South Broward Research — Miramar, Florida, United States (enrolling)
• Suncoast Clinical Research, Inc. — New Port Richey, Florida, United States (enrolling)
• West Coast Medical Associates — New Port Richey, Florida, United States (enrolling)
• MediSphere Medical Research Center, LLC — Evansville, Indiana, United States (enrolling)
• Monroe Biomedical Research — Louisville, Kentucky, United States (enrolling)
• Aa Mrc Llc — Flint, Michigan, United States (enrolling)
• Albuquerque Clinical Trials, Inc. — Albuquerque, New Mexico, United States (enrolling)
• Rochester Clinical Research, LLC — Rochester, New York, United States (enrolling)
• Medication Management LLC — Greensboro, North Carolina, United States (enrolling)
• Tokyo-Eki Center-Building Clinic — Chuo-ku, Tokyo, Japan
• Medical Corporation Heishinkai ToCROM Clinic — Shinjuku-ku, Tokyo, Japan
• University Clinical Investigators, Inc. — Tustin, California, United States
• York Clinical Research, LLC — Norfolk, Virginia, United States
• Medical Corporation Heishinkai OCROM Clinic — Suita, Osaka, Japan
• Tokyo Center Clinic — Chuo-ku, Tokyo, Japan
• Fukuwa Clinic — Chuo-ku, Tokyo, Japan

Full record on ClinicalTrials.gov

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