Combined TMS-tSCS for Lower Limb Rehabilitation in Chronic Incomplete SCI

Starting soon · Not applicable

Conditions studied: Spinal Cord Injuries (SCI)

In brief

he goal of this clinical trial is to learn if combined brain and spinal cord stimulation using TMS-tSCS can improve leg strength and walking recovery in adults with chronic incomplete spinal cord injury. The main questions it aims to answer are: Does combined TMS-tSCS improve lower limb motor function more than tSCS alone? Is combined TMS-tSCS safe and does it improve walking speed, independence, muscle activity, spasticity, and nerve pathway function? Researchers will compare combined TMS-tSCS with tSCS alone with sham TMS to see if adding brain stimulation leads to better recovery than spinal stimulation alone. Participants will: Attend 32 treatment sessions over 16 weeks. Receive either combined TMS-tSCS or tSCS with sham TMS. Undergo assessments of leg strength, walking speed, daily function, muscle stiffness, muscle activity, and nerve pathway function before and after treatment.

Key facts

Study ID

NCT07595497

Run by

National University Hospital, Singapore

People needed

24

Starts

2027-01-01

Expected to finish

2028-03-01

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-65 years at enrolment
• Chronic traumatic spinal cord injury, defined as ≥12 months post-injury
• Incomplete spinal cord injury, AIS grade C or D
• Neurological level of injury from C2 to L1
• Baseline Lower Extremity Motor Score (LEMS) >10 points
• Medically stable
• Able to provide informed consent
• Able to commit to the full study duration
• Able to attempt the 10-Meter Walk Test and 6-Minute Walk Test, with or - without assistive devices and standby assistance

You may not qualify if…

• History of seizures or epilepsy
• Implanted electronic devices, such as: Pacemaker, Cochlear implant, Deep brain stimulator, Spinal cord stimulator, Metallic implants in the head or spine
• Pregnancy or planned pregnancy
• Active psychiatric disorder or cognitive impairment
• Concomitant neurological conditions, such as: Stroke, Traumatic brain injury and Neuropathy
• Skin breakdown at electrode sites
• Current participation in another clinical trial
• History of skull surgery or craniotomy
• Use of medications that alter cortical excitability within the past 2 weeks

Where it is running

• Alexandra Hospital/ National University Hospital, Singapore — Singapore, Singapore

Full record on ClinicalTrials.gov

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