Left Atrial Pressure-Guided Heart Failure Optimization During Atrial Fibrillation Ablation (LAP AF-HF)

Running, not enrolling

Conditions studied: Atrial Fibrillation (AF), Heart Failure, Catheter Ablation, Guideline Implementation

In brief

This study examines whether measuring blood pressure inside the left upper chamber of the heart during a procedure to treat an irregular heartbeat called atrial fibrillation can help identify patients who would benefit from heart failure medications. During atrial fibrillation ablation, a catheter crosses into the left atrium, allowing direct measurement of left atrial pressure. When the pressure is elevated (15 mmHg or higher), it may indicate that the heart is under strain from unrecognized or undertreated heart failure. Patients with elevated left atrial pressure during ablation are referred for heart failure evaluation and medication optimization within 24 hours of the procedure. The study compares outcomes in these patients to a group of patients who had the same elevated pressures but received standard care without a structured heart failure evaluation. The study measures whether the heart failure treatment pathway leads to greater use of recommended heart failure medications, improvements in heart pumping function and heart chamber size, and reduction in irregular heartbeat episodes over the following year

Key facts

Study ID

NCT07594886

Run by

Medical College of Wisconsin

People needed

300

Starts

2024-02-12

Expected to finish

2029-12-31

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Referred and presented for catheter ablation of atrial fibrillation
• Able to provide written informed consent
• Intraprocedural mean left atrial pressure 15 mmHg or greater measured immediately after transseptal puncture -- Written informed consent (prospective cohort 2024- onwards) or institutional review board waiver of consent (historical cohort 2022-2023)

You may not qualify if…

• No additional exclusion criteria

Where it is running

• Heart and Vascular Center - Center for Advanced Care - Froedtert Hospital — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

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