A Study of HDM1002 Tablets on Cardiac Repolarization in Healthy Subjects

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: Healthy Adult Subject

In brief

The aim of this trial is to evaluate the effect of a single oral dose of HDM1002 tablets on the QT/QTc interval in healthy subjects.

Key facts

Study ID

NCT07594847

Run by

Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

People needed

72

Starts

2026-03-07

Expected to finish

2026-11-06

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The subject has voluntarily signed a written informed consent form.
• Male or female; age between 18 and 45 years (inclusive).
• Subject's weight ≥50 kg, with a body mass index (BMI) between 19.0 and 28.0 kg/m2, inclusive. BMI = weight (kg) / height2 (m2).
• Medical history inquiry, physical examination, laboratory test items, and other trial-related tests at screening are all normal or show mild abnormalities with no clinical significance, and the subject is judged to be eligible by the clinical research physician.
• The subject is able to communicate well with the investigator and comply with the protocol requirements to complete the study.

You may not qualify if…

• History of or current neurological/psychiatric, respiratory, cardiovascular, gastrointestinal, hematological and lymphatic, endocrine, or musculoskeletal system diseases, hepatic or renal insufficiency, or any other disease or physiological condition that may affect the study results;
• Subjects with a personal or family history of medullary thyroid cancer (MTC), thyroid C-cell hyperplasia, or multiple endocrine neoplasia type 2 (MEN2);
• History of chronic pancreatitis or an episode of acute pancreatitis within 3 months prior to screening;
• History of a cholecystitis episode within 3 months prior to screening;
• History of allergy to HDM1002, moxifloxacin hydrochloride tablets, other fluoroquinolones or quinolones, or any of the excipients; or history of food allergy, or a specific allergy history (asthma, urticaria, eczema, etc.);
• Clinically significant major illness or undergone major surgery within 3 months prior to the trial;
• Blood donation within 3 months, or plans to donate blood during this study, or transfusion or blood loss ≥200 mL within 4 weeks prior to the trial;
• Has consumed a special diet, engaged in strenuous exercise, or had other factors that affect drug absorption, distribution, metabolism, and excretion within 48 hours prior to dosing;
• Pregnant or lactating, or has a positive blood pregnancy test result;
• The investigator believes that the subject has any other condition that makes them unsuitable for participation in this clinical trial.

Where it is running

• PKUcare Luzhong Hospital — Zibo, Shangdong, China (enrolling)

Full record on ClinicalTrials.gov

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