The Effect Of Lisinopril On Polycythemia
Starting soon · Phase 4
Conditions studied: Polycythemia
In brief
The purpose of this study is to evaluate the effect of the (angiotensin-converting enzyme) ACE inhibitor lisinopril on hemoglobin, hematocrit, and erythropoietin levels in patients with secondary polycythemia due to high-oxygen-affinity hemoglobin variants, oxygen-sensing pathway mutations, or other unexplained and potentially irreversible forms of erythrocytosis. This study aims to determine whether ACE inhibition can effectively reduce excessive erythrocytosis by modulating erythropoietin production.
Key facts
- Study ID
- NCT07594535
- Run by
- Mayo Clinic
- People needed
- 30
- Starts
- 2026-07-01
- Expected to finish
- 2029-07-01
- Last updated by the study team
- 2026-05-18
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Hemoglobin in Men: >16.5 g/dL (10.3 mmol/L).
- Hemoglobin in Women >16.0 g/dL (10.0 mmol/L).
- BMI 18-40 kg/m2.
You may not qualify if…
- Positive JAK2 gene linked to Polycythemia Vera.
- Current smoker or previous heavy smoker (>15 pack years) who quit less than 12 months prior to enrollment.
- Resting SpO₂ ≤ 94% on room air.
- Current or recent (within the past 6 months) use of testosterone or androgen supplementation.
- Any confounding respiratory or renal disease, including diagnosed or suspected sleep apnea, or stage 3 and up of chronic kidney disease.
- Any confounding hematologic disease that may alter hemoglobin level.
- Currently treated with ACE inhibitors.
- Currently treated with potassium-sparing diuretics.
- Currently on SGLT2 or use within 4 weeks prior to screening.
- Baseline systolic blood pressure ≤90 mmHg.
- Baseline systolic blood pressure >160 mmHg or diastolic blood pressure >100 mmHg.
- Occupational exposure associated with chronically elevated COHb (auto repair, etc.).
- History of anaphylaxis or angioedema.
- Pregnant or breastfeeding.
Where it is running
- St. Mary's Hospital — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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