Trial Comparing LATTICE Radiotherapy vs Moderately Dose-escalated Palliative Radiation for Patients With Metastases.
Starting soon · Phase 2
Conditions studied: Metastases, Metastatic Cancer
In brief
Unblinded, randomized study of 5-fraction LATTICE radiotherapy (20 Gy with an SIB to 66.7 Gy in 5 fractions) versus moderately dose-escalated palliative radiation (25 Gy in 5 fractions)
Key facts
- Study ID
- NCT07594431
- Run by
- Stanford University
- People needed
- 80
- Starts
- 2026-08-01
- Expected to finish
- 2028-08-01
- Last updated by the study team
- 2026-05-18
Who can join
Age: 12 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically, cytologically, or radiographically confirmed diagnosis of metastatic cancer
- One to two metastases in non-brain sites that are amenable to LATTICE radiotherapy: >2.5 cm in short axis (dimension on axial imaging that is perpendicular to the longest dimension); bone metastasis can be included if the extraosseous component is >2.5 cm in short axis
- Age ≥12
- ECOG Performance Status 0-2
- For patients age 12-16, Lansky Play-Performance score 50-100
- Negative serum or urine pregnancy test within 2 weeks prior to enrollment of people of childbearing potential
- All patients and/or their parents or legal guardians must sign a written informed consent. For any child less than 18 years of age, assent must also be obtained in addition to parental or legal guardian consent.
You may not qualify if…
- Prior radiation therapy to the tumor to be treated
- Active pregnancy
- Diseases that place the patient at high risk of radiation complications including lupus, scleroderma, Li Fraumeni syndrome
- The tumor to be treated is from a hematologic malignancy such as lymphoma or myeloma
Where it is running
- Stanford University — Palo Alto, California, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.