Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF
Starting soon · Not applicable
Conditions studied: Acute on Chronic Liver Failure (ACLF)
In brief
Clinical trial The goal of this clinical trial is to learn if a liver support protocol works to treat Liver failure in adults. The main questions it aims to answer are: * Does hemoadsorption plus half-dose plasma exchange provide support to liver failure patients until recovery or transplant * What medical problems do participants have during the technique? Researchers will compare DPMAS plus half-dose plasma exchange with conventional treatment to evaluate a gain in recovery Participants will: * Be submitted to DPMAS plus half dose plasma exchange daily according to protocol. * Monitoring will be continuous in the ICU
Key facts
- Study ID
- NCT07593638
- Run by
- Unidade Local de Saude do Nordeste
- People needed
- 240
- Starts
- 2026-07-01
- Expected to finish
- 2028-01-01
- Last updated by the study team
- 2026-05-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Written informed consent for participation in the study
- Admission to the ICU with a diagnosis of ACLF of reversible etiology (infection, bleeding, alcohol-related, toxic, etc.)
- Total bilirubin ≥ 12 mg/dL and INR ≥ 1.5
- On the waiting list for liver transplantation or not a candidate for transplantation but with an indication for supportive therapy
You may not qualify if…
- Refusal to provide consent
- Pregnancy
- Expected survival < 24 hours due to disease severity (hemodynamic instability requiring norepinephrine > 0.20 mcg/kg/min and/or mechanical ventilation with PaO₂/FiO₂ < 150 and/or non-hepatic coma)
- ACLF severity greater than CLIF-C ACLF grade 3
- Advanced organ dysfunction: Pulmonary (GOLD stage 3 or 4) and/or Cardiac (NYHA functional class III or IV)
- Advanced or metastatic oncological disease (life expectancy < 6 months)
- Marked frailty syndrome or secondary sarcopenia
- Participation in another clinical trial within the previous 3 months
Where it is running
- Unidade Hospitalar de Bragança — Bragança, Braganza District, Portugal
Full record on ClinicalTrials.gov
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