Application of Neuro-electrostimulation as a Treatment for Patients With Dry Mouth

Recruiting now · Not applicable

Conditions studied: Saliva Altered

In brief

Hyposalivation is a condition that has increased in frequency, primarily due to the degeneration of salivary glands caused by aging, polypharmacy, chronic or autoimmune diseases, or radiation treatments. Most of these factors are associated with the elderly, a growing demographic due to the aging population. Therefore, addressing this condition has become crucial in our population, as has understanding how it affects their quality of life. Given that saliva plays a vital role in maintaining the oral mucosa, tooth structure, initiating digestion, and even speech, a long-term treatment to stimulate salivary production would be extremely helpful in resolving these problems. Currently, only palliative measures that temporarily cover or lubricate the oral cavity and its structures are available. Among the most innovative treatments is neuroelectrical stimulation (TENS) as an adjunct in the therapy of dry mouth, which has shown improvement; however, this improvement has not been quantified through objective measurements that would allow for determining the quantity and quality of saliva, nor in the long term. Likewise, the patient's quality of life affected by this condition has not been assessed. Therefore, the objective of this project is to evaluate the effect on salivary quality and quantity after the application of neuroelectrical stimulation as a treatment for patients with dry mouth, as well as their quality of life.

Key facts

Study ID: NCT07593495
Run by: Universidad Autonoma del Estado de Mexico
People needed: 35
Starts: 2026-02-01
Expected to finish: 2027-07-31
Last updated by the study team: 2026-05-18

Who can join

Age: 12 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Patients diagnosed with dry mouth symptoms.
Patients who wish to participate in the study.
Patients who allow saliva samples to be collected before, during, and after treatment.
Patients who allow the application of transcutaneous electrical nerve stimulation (TENS).
Patients who do not have any active oral infections.
Patients who attend all sialometry assessments and physiotherapy sessions and complete both quality of life questionnaires (initial and final).

You may not qualify if…

Patients with any other mucosal alteration.
Patients who do not wish to participate in the study.
Patients who do not allow the collection of saliva samples.
Patients who do not allow the application of transcutaneous electrical nerve stimulation (TENS).
Patients with any infectious process in the oral cavity.
Because the study requires the use of low-frequency pulse currents, participants with pacemakers, defibrillators, hearing aids, or cochlear implants will also be excluded from the study.

Where it is running

Clinic of Oral Medicine and Pathology "Orocentro", School of Dentistry, Autonomous University of the State of Mexico — Toluca, State of Mexico, Mexico (enrolling)

Full record on ClinicalTrials.gov

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