Phase 1, Safety and Tolerability Study of XmAb541 and XmAb808 in Advanced Solid Tumors

Starting soon · Phase 1

Conditions studied: Ovarian Cancer

In brief

The primary purpose of this study is to determine whether the investigational drug XmAb541 in combination with XmAb808 is safe and well tolerated, and to determine an optimal and safe dose(s) for further study. The study will also evaluate the effect of XmAb541 in combination with XmAb808 on tumor outcomes.

Key facts

Study ID

NCT07593092

Run by

Xencor, Inc.

People needed

90

Starts

2026-06-01

Expected to finish

2028-12-01

Last updated by the study team

2026-05-18

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years.
• CLDN6+ tumor
• Histological or cytological documentation of locally advanced, recurrent, or metastatic high grade serous ovarian carcinoma (HGSOC) including fallopian tube or primary peritoneal origin
• Adequate Eastern Cooperative Oncology Group performance status
• Life expectancy ≥ 3 months
• Adequate organ function

You may not qualify if…

• Prior exposure to a CLDN6 targeting immune cell engager
• Patients with treated brain metastases may participate, provided they are radiologically stable.
• Active known or suspected autoimmune disease
• Have any condition requiring systemic treatment with corticosteroids, prednisone equivalents, or other immunosuppressive medications within 14 days prior to first dose of study drug
• Clinically significant cardiovascular, pulmonary or gastrointestinal disease
• Active viral hepatitis B or hepatitis C

Where it is running

• Xencor Investigative Site — Detroit, Michigan, United States
• Xencor Investigative Site — Omaha, Nebraska, United States
• Xencor Investigative Site — Lake Success, New York, United States
• Xencor Investigative Site — New York, New York, United States
• Xencor Investigative Site — The Bronx, New York, United States
• Xencor Investigative Site — Columbus, Ohio, United States
• Xencor Investigative Site — Oklahoma City, Oklahoma, United States
• Xencor Investigative Site — Fort Worth, Texas, United States
• Xencor Investigative Site — Houston, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.