Physical Activity Level at Home in CMT1A Patients: Wearable Sensor Assessment

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Conditions studied: Charcot-Marie-Tooth Disease, Type IA, Peripheral Neuropathy Hereditary, Motor Activity, Walking, Difficulty, Neuromuscular Diseases

In brief

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common hereditary peripheral neuropathy, affecting approximately 26,000 patients in France. It presents as chronic and progressive sensorimotor deficits predominantly affecting the distal lower limbs, with onset typically in childhood. There is currently no specific pharmacological treatment; management remains symptomatic. This research will: In the long run, validated wearable sensors could improve patient follow-up, personalize rehabilitation, and support the design of clinical trials for CMT1A - including trials of the novel "Nano-Cur" treatment currently under development.

Key facts

Study ID

NCT07591779

Run by

University Hospital, Limoges

People needed

60

Starts

2026-06-01

Expected to finish

2027-06-30

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Genetically confirmed diagnosis of CMT1A (PMP22 duplication on chromosomal analysis)
• Followed at the National Reference Centre for Rare Peripheral Neuropathies (Service de Neurologie, CHU de Limoges) and/or having undergone gait analysis at the Quantified Movement Analysis Laboratory (Laboratoire d'AQM), Service de Médecine Physique et de Réadaptation, CHU de Limoges
• Ability to walk independently (with or without walking aids)
• Informed consent obtained
• Affiliated to French social security system

You may not qualify if…

• Other associated neurological condition that could independently affect walking or motor activity
• Inability to wear the sensor device (skin allergy, sensory intolerance)
• Inability to comply with study procedures (cognitive impairment, no fixed domicile)
• Participation in another interventional study during the same period
• Pregnant or breastfeeding women
• Patients under legal protection (guardianship or curatorship)

Where it is running

• Chu de Limoges — Limoges, France

Full record on ClinicalTrials.gov

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