Enucleation Ratio as a Novel Predictor of Symptomatic Improvement After HoLEP

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Conditions studied: Benign Prostate Obstruction (BPO)

In brief

The goal of this observational study is to determine whether the rate of prostate tissue removed during surgery relative to the preoperative total prostate volume (referred to as the "enucleation ratio") predicts symptomatic improvement 3 months after HoLEP. The main question it aims to answer is: \- What is the minimum enucleation ratio required to achieve clinically important symptomatic improvement? (Symptomatic improvement is referred to as a threshold of having an International Prostate Symptom Score (IPSS) lower than 8 points, which is determined by the American Urological Association (AUA) and European Association of Urology(EAU)).

Key facts

Study ID

NCT07591688

Run by

Ondokuz Mayıs University

People needed

400

Starts

2026-07-01

Expected to finish

2027-03-30

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Men aged 18 years pr older who are planned to undergo HoLEP.
• Participants who are willing to give informed consent.
• Participants who have moderate to severe LUTS (referring to IPSS score 8 points or more).
• No history of previous prostate or urethral surgery.

You may not qualify if…

• Unwillingness to provide informed consent.
• Unwillingness to provide contact information or unreachability during follow-up periods.
• Incidental diagnosis of a urogenital malignancy requiring primary treatment after enrollment (e.g., bladder tumor, renal cell carcinoma, testicular tumor).

Where it is running

• Ondokuz Mayis University, Faculty of Medicine, Department of Urology — Samsun, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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