Effectiveness of Positive Deviance/Hearth in Treating Uncomplicated Moderate Acute Malnutrition in Children 6-59 Months in Mymensingh Division, Bangladesh

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Conditions studied: Moderate Acute Malnutrition (MAM), Undernutrition, Wasting

In brief

The goal of this clinical trial (cluster randomized controlled trial) is to learn whether a Positive Deviance/Hearth (PDH) intervention can effectively treat moderate acute malnutrition (MAM) and reduce relapse compared to standard care in children aged 6-59 months diagnosed with MAM in Bangladesh. The main questions it aims to answer are: * Does the PDH intervention improve recovery rates among children with MAM? * Does the PDH intervention reduce relapse to MAM or progression to severe acute malnutrition (SAM) after recovery? Researchers will compare communities receiving the PDH intervention to communities receiving standard nutrition care (e.g., usual counseling or supplementary feeding programs) to see if PDH leads to better nutritional recovery and sustained outcomes. Participants will: * Take part in a 12-day "Hearth" nutrition education program where caregivers prepare and feed children nutrient-dense meals using local foods * Receive 2 weeks of home follow-up visits by volunteers after the Hearth sessions, along with ongoing growth monitoring and counseling twice per month * Undergo periodic anthropometric assessments (weight, height/length, Mid-upper arm circumference (MUAC)) at key time points

Key facts

Study ID: NCT07591064
Run by: World Vision US
People needed: 400
Starts: 2026-05-16
Expected to finish: 2026-12-17
Last updated by the study team: 2026-05-15

Who can join

Age: 1 and older, up to 5. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Children 6-52.9 months at Baseline. This is so that children are 6-59 months by end of study (6-7 months from baseline)
Children with MAM (WHZ/WLZ <-2 and ≥-3 and/or MUAC <125mm and ≥115mm)
No Medical Complications (passes IMCI screening questions)
No oedema
Child does not deteriorate to SAM (WHZ/WLZ<-3 and/or MUAC<115mm) because child should be referred to health centre
Caregiver refuses to receive age-appropriate immunization, Vitamin A and deworming minimum 2 weeks before PDH begins
Child is not planning to live outside the study area routinely for more than 2 weeks during the 3 months of the study
Written/Oral consent is given by Parent/Caregiver to participate in the study

You may not qualify if…

Child is not between 6-52 months of age at Baseline
Child does not meet the inclusion criteria for WHZ/WLZ and/or MUAC; (WHZ/WLZ <-2SD and ≥-3SD and/or MUAC <125mm and ≥115mm);
Child has oedema;
Child has medical complications and/or does not pass the IMCI screening including fever, nausea/vomiting, acute respiratory illness (refer to Study Protocol V2.0, 19 Feb 2026);
Deteriorates to SAM and must be removed from the study and referred to the health centre for specially formulated food (SFF) treatment;
Refuses to receive minimum 2 weeks before the intervention begins, age-appropriate immunization and Vitamin A and deworming in the past 6 months;
Child lives outside the study area routinely or will be outside of the study area for more than 2 weeks in the upcoming 3 months
Parent/Caregiver unable or unwilling to attend PDH from start;
Parent/Caregiver does not provide written or oral consent to screen for the trial;
Parent/Caregiver does not provide informed consent for the study; and
any other reason.

Where it is running

World Vision Bangladesh — Purbadhala, Mymensingh, Bangladesh

Full record on ClinicalTrials.gov

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