D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients
Recruiting now
Conditions studied: Chronic Obstructive Pulmonary Disease (COPD), Mechanical Ventilator Weaning
In brief
This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success from invasive mechanical ventilation in COPD patients. Diaphragmatic ultrasound measurements will be performed during spontaneous breathing trials, and patients will be followed for 72 hours after extubation to assess weaning outcomes.
Key facts
- Study ID
- NCT07590362
- Run by
- Sohag University
- People needed
- 100
- Starts
- 2026-04-15
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-05-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Mechanically ventilated COPD patients fulfilling standard weaning readiness criteria.
- Invasive mechanical ventilation for more than 24 hours before spontaneous breathing trial.
- Hemodynamically stable without significant vasopressor support.
- Adequate oxygenation with FiO2 ≤ 0.5 and PEEP ≤ 8 cmH2O .
- Preserved mental status and ability to initiate spontaneous breathing.
- Successful tolerance of spontaneous breathing trial conducted on CPAP mode with pressure support ≤ 8 cmH2O.
You may not qualify if…
- Refusal of consent
- Neuromuscular disease, phrenic nerve palsy, or diaphragmatic paralysis.
- Large pneumothorax or pathology interfering with ultrasound assessment.
- Terminal extubation.
- Recent major thoracic surgery.
- Poor sonographic window despite repeated attempts.
Where it is running
- Sohag University Hospital — Sohag, Sohag Governorate, Egypt (enrolling)
Full record on ClinicalTrials.gov
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