Behavioral Rigidity in Residential Treatment for Substance Use Disorder (RIG-TD)

Enrolling by invitation

Conditions studied: Substance Use Disorder (SUD), Anxiety, Depression Anxiety Disorder

In brief

Behavioral rigidity, the tendency to maintain inflexible patterns of thinking and acting despite changing circumstances, is a common feature in substance use disorders, depression, and anxiety. This observational study aims to measure behavioral rigidity as a dynamic, transdiagnostic process in patients undergoing residential treatment for substance use. Using a longitudinal intensive repeated-measures design, participants complete weekly assessments of cognitive reactivity (Automatic Thoughts Questionnaire-8 item version, ATQ-8), behavioral activation (Behavioral Activation for Depression Scale, BADS), and experiential avoidance. A Behavioral Rigidity Index (BRI) is derived from these measures. Additionally, natural language processing (NLP) is applied to therapy session transcripts to quantify linguistic absolutism (e.g., use of words like "always," "never") and affective polarity. Bayesian multilevel models examine whether rigidity predicts current and next-week clinical status. The study also explores whether linguistic markers add unique predictive value beyond self-reports. Results may inform personalized monitoring and interventions targeting psychological inflexibility in addiction treatment.

Key facts

Study ID

NCT07590115

Run by

Lauro Gutiérrez Castro

People needed

35

Starts

2025-05-25

Expected to finish

2026-07-01

Last updated by the study team

2026-05-18

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Minimum stay of four weeks in the residential treatment program
• At least three complete longitudinal measurement time points
• Ability to read, understand, and respond to self-report instruments in Spanish
• Capacity to participate in structured clinical sessions
• Diagnosis of substance use disorder (clinical assessment)

You may not qualify if…

• Severe neurocognitive impairment
• Acute psychotic symptoms
• Incomplete longitudinal records (less than three time points)
• Inability to complete self-report measures due to cognitive or language barriers

Where it is running

• Under The Tree Potrerillos — Potrerillos, Jalisco, Mexico

Full record on ClinicalTrials.gov

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