Biomaterials Exposed to Oral Environment: Which One is the Appropriate Option?
Enrolling by invitation · Not applicable
Conditions studied: Tooth Extraction Site Healing, Alveolar Ridge Preservation
In brief
After tooth extraction, bone loss can compromise future dental implant treatment. Dentists often use biomaterials to preserve bone, but in many cases these materials are left exposed to the oral environment, where saliva and bacteria may affect healing. This study will investigate how different collagen-based biomaterials behave when exposed in the mouth, evaluating healing, bone changes, bacterial contamination, and patient experience. Sixty patients will be included in a randomized clinical trial comparing two commonly used biomaterials and natural healing. The results will help clinicians choose safer and more effective treatments, improving outcomes for patients undergoing tooth extraction and future implant rehabilitation.
Key facts
- Study ID
- NCT07589751
- Run by
- Pontificia Universidade Católica do Rio Grande do Sul
- People needed
- 60
- Starts
- 2026-05-01
- Expected to finish
- 2027-10-01
- Last updated by the study team
- 2026-05-15
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adult subjects in need of non-molar maxillary or mandibular single tooth extraction at the PUCRS university - Porto Alegre - Brazil.
- > 18 years of age
- non-molar tooth indicated for extraction
- intact sockets upon extractions
- Patients using removable provisional prosthesis (accessible to remove possible contact with surgical site) or patients without prosthesis after tooth extraction.
You may not qualify if…
- Current smokers
- Uncontrolled Diabetes Mellitus
- Mandibular incisors
- Patients receiving chemo or radiotherapy or history of these treatments in the previous 5 years
- Any other disease or medications that may compromise normal wound healing
- Unwilling or unable to sing the informed consent
Where it is running
- PUCRS — Porto Alegre, Rio Grande do Sul, Brazil
Full record on ClinicalTrials.gov
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