Cf-PWV and TyG Index Study

Starting soon

Conditions studied: Hypertension, Insulin Resistance Syndrome, Arterial Stiffness, Cardiovascular Risk, Blood Pressure Variability

In brief

This study aims to investigate how metabolic health is related to arterial stiffness and daily blood pressure patterns. High blood pressure is one of the leading causes of heart disease worldwide, but cardiovascular risk is not determined only by average blood pressure values. Changes in blood vessel structure and metabolic function also play an important role in the development of cardiovascular disease. Arterial stiffness reflects how flexible or rigid the arteries are. It can be measured using carotid-femoral pulse wave velocity (cf-PWV), which is considered a reliable and widely used method to assess vascular health. Increased arterial stiffness is associated with aging and higher cardiovascular risk. At the same time, metabolic factors such as insulin resistance and central obesity are strongly linked to vascular damage. The triglyceride-glucose (TyG) index is a simple measure derived from routine blood tests and has been shown to reflect insulin resistance. Additional derived indices that combine TyG with body measurements (such as waist circumference and body mass index) may provide an even more comprehensive evaluation of metabolic risk. Another important aspect of cardiovascular regulation is how blood pressure changes throughout the day. Blood pressure naturally rises in the morning after waking, a phenomenon known as the morning blood pressure surge. When this increase is excessive, it has been associated with a higher risk of cardiovascular events such as stroke and heart attack. This study will evaluate the relationship between metabolic indices, arterial stiffness, and morning blood pressure patterns in adults undergoing ambulatory blood pressure monitoring as part of routine clinical care. The study will include both previously collected data and new participants evaluated using standardized methods. No additional interventions will be performed, and all data will be collected as part of routine clinical evaluation. The results of this study may help improve cardiovascular risk assessment by integrating simple metabolic markers with vascular measurements and daily blood pressure behavior, potentially allowing earlier identification of individuals at higher risk.

Key facts

Study ID

NCT07589374

Run by

Hospital de Base

People needed

800

Starts

2026-07-01

Expected to finish

2028-07-01

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 18 to 65 years;
• Both sexes;
• Referred for ambulatory blood pressure monitoring (ABPM) as part of routine clinical evaluation;
• Not receiving antihypertensive medication at the time of assessment;
• Availability of valid 24-hour ABPM data;
• Availability of carotid-femoral pulse wave velocity (cf-PWV) measurement;
• Availability of fasting laboratory data, including glucose and triglycerides, for calculation of the triglyceride-glucose (TyG) index;
• Ability and willingness to provide written informed consent (for prospectively recruited participants).

You may not qualify if…

• Use of antihypertensive medication at the time of evaluation;
• Cardiac arrhythmias that may interfere with accurate blood pressure or pulse wave velocity measurements;
• Invalid or poor-quality ambulatory blood pressure monitoring (ABPM) recordings;
• Inability to obtain reliable carotid-femoral pulse wave velocity (cf-PWV) measurements;
• Presence of severe vascular disease or conditions affecting arterial waveform assessment;
• Missing essential clinical, laboratory, or hemodynamic data required for the primary analysis;
• Pregnancy;
• Refusal or inability to provide informed consent (for prospectively recruited participants).

Where it is running

• Medicine School of São José do Rio Preto — São José do Rio Preto, São Paulo, Brazil

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.