POCD After Major Gynecologic Surgery

Recruiting now

Conditions studied: Postoperative Cognitive Dysfunction, Perioperative Neurocognitive Disorder

In brief

This prospective observational cohort study aims to determine the incidence of early postoperative cognitive dysfunction (POCD) in patients undergoing major gynecological surgery. Cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA) preoperatively and on postoperative day 3. POCD will be defined as a ≥20% relative decline or ≥2-point decrease in MoCA score. The study will also evaluate the association between POCD and perioperative clinical, surgical, and inflammatory parameters.

Key facts

Study ID

NCT07589348

Run by

Fatihhan Zeytun

People needed

72

Starts

2026-05-06

Expected to finish

2026-09-15

Last updated by the study team

2026-06-12

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients aged ≥18 years
• Scheduled for elective major gynecological surgery under general anesthesia
• Total abdominal hysterectomy and/or bilateral salpingo-oophorectomy
• Open or laparoscopic surgical approach
• Ability to complete the Turkish version of the Montreal Cognitive Assessment (MoCA)
• Ability to understand and provide written informed consen

You may not qualify if…

• Pre-existing dementia or major neurocognitive disorder
• History of cerebrovascular event within the previous 3 months
• Severe visual or hearing impairment preventing cognitive assessment
• Emergency or hemodynamically unstable surgery
• Planned postoperative sedation or mechanical ventilation longer than 72 hours
• Postoperative delirium detected during assessment
• Inability to communicate or cooperate
• Refusal to participate

Where it is running

• University of Health Sciences Kocaeli City Hospital — İzmit, Kocaeli, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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