Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease

Recruiting now · Not applicable

Conditions studied: Stable Coronary Artery Disease, Acute Coronary Syndromes, Critical Limb Ischemia, Intermittent Claudication

In brief

Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages. This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.

Key facts

Study ID

NCT07588295

Run by

Maria Cecilia Hospital

People needed

60

Starts

2024-03-18

Expected to finish

2026-12-01

Last updated by the study team

2026-05-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with chronic coronary artery disease;
• Patients with no-ST elevation acute coronary syndrome;
• Patients with chronic claudication (Rutherford II-III)
• Patients with critical limb ischemia (Rutherford IV-V).

You may not qualify if…

• Severe renal dysfunction
• Severe valve disease
• Advanced heart failure
• Advanced liver disease
• Chronic inflammatory or autoimmune disease
• Use of antinflammatory drugs
• Acute infection
• Recent surgical procedures

Where it is running

• Maria Cecilia Hospital — Cotignola, Ravenna, Italy (enrolling)

Full record on ClinicalTrials.gov

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