Granulation Tissue From Residual Periodontal Pockets

Enrolling by invitation

Conditions studied: Periodontitis

In brief

This observational study aims to describe the histopathological features of granulation tissue (GT) found in residual periodontal pockets at the time of surgical intervention, after completion of the first two steps of periodontal therapy, according to EFP guidelines (Sanz et al., 2020). A secondary objective was to analyze GT characteristics in relation to clinical outcomes (e.g., defect type, probing depth reduction and clinical attachment gain) in order to identify possible statistical associations between tissue patterns and clinical improvements.

Key facts

Study ID

NCT07587606

Run by

University of Roma La Sapienza

People needed

21

Starts

2026-05-07

Expected to finish

2026-07-30

Last updated by the study team

2026-05-14

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-75 years
• Full Mouth Plaque Score (FMPS) <15% at re-evaluation
• Full Mouth Bleeding Score (FMBS) <15% at re-evaluation
• At least one site with probing depth (PPD) ≥5 mm after non-surgical therapy
• Written informed consent
• Good compliance throughout periodontal therapy

You may not qualify if…

• Pregnancy or breastfeeding
• Use of systemic or local antibiotics in the previous 3 months
• Smoking
• Use of anti-inflammatory or anticoagulant/antiplatelet drugs
• Systemic, cardiovascular, or infectious diseases affecting periodontal health
• Dental contraindications to surgery (fractures, untreated endodontic lesions, mobility > grade 2, or faulty restorations)
• Non-compliant patients
• History of periodontal therapy in the previous year
• Ongoing orthodontic treatment

Where it is running

• Sapienza University of Rome, Department of Oral and Maxillofacial Sciences, Section of Periodontology — Roma, Roma, Italy

Full record on ClinicalTrials.gov

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