Phase 1b/2a Study of EYC-0305 in Patients With Neovascular Age-related Macular Degeneration
Recruiting now · Phase 1/Phase 2
Conditions studied: Neovascular (Wet) Age-Related Macular Degeneration
In brief
This Phase 1b/2a study will primarily investigate the safety and tolerability of EYC-0305 delivered by intravitreal (IVT) injection every 24 weeks in patients with neovascular (wet) age-related macular degeneration (AMD). The pharmacokinetics (PK) and immunogenicity of EYC-0305, and the effect on disease activity and vision will also be evaluated.
Key facts
- Study ID
- NCT07587515
- Run by
- Eyconis INC.
- People needed
- 30
- Starts
- 2026-05-19
- Expected to finish
- 2028-05-01
- Last updated by the study team
- 2026-07-07
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men or women 50 years and older with neovascular (wet) AMD meeting all study-specified eligibility criteria
- Willing and able to comply with clinic visits and study-related procedures
- Provide signed informed consent
You may not qualify if…
- Known hypersensitivity or known allergy that would preclude study drug administration
- Inability to obtain ophthalmic imaging, eg, due to media opacity, inadequate pupillary dilation, allergy to fluorescein dye or lack of venous access
- Uncontrolled diabetes mellitus
- History of cerebrovascular accident (CVA) or myocardial infarction within 180 days of the Day 1 visit
- Renal failure, dialysis, or history of renal transplant
- Concurrent psychiatric or medical condition that in the opinion of the Investigator will interfere with study participation or completion
- Pregnant or breastfeeding women
Where it is running
- Beverly Hills, CA — Beverly Hills, California, United States (enrolling)
- Wake Forest, NC — Wake Forest, North Carolina, United States (enrolling)
- Erie, PA — Erie, Pennsylvania, United States (enrolling)
- Bellaire, TX — Bellaire, Texas, United States (enrolling)
- McAllen, TX — McAllen, Texas, United States (enrolling)
- The Woodlands, TX — The Woodlands, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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