Molecular Profiling for Risk Stratification in Appendiceal Cancer

Recruiting now

Conditions studied: Appendiceal Cancer, Appendiceal Adenocarcinoma

In brief

This study investigates integrated epigenetic and epitranscriptomic features of appendiceal cancer using archived tumor tissue specimens from the same patient cohort. The study includes DNA methylation profiling and m6A epitranscriptomic profiling to define molecular subtypes, evaluate associations with clinicopathologic features, and develop molecular risk scores for prognostic stratification. The primary goal is to determine whether DNA methylation- and m6A-based molecular features can complement conventional histopathologic grading and improve risk stratification.

Key facts

Study ID

NCT07587268

Run by

City of Hope Medical Center

People needed

400

Starts

2026-05-01

Expected to finish

2027-01-01

Last updated by the study team

2026-06-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with histologically confirmed appendiceal adenocarcinoma or appendiceal cancer.
• Availability of archived tumor tissue suitable for molecular profiling.
• Availability of tissue for DNA methylation profiling, m6A epitranscriptomic profiling, or both.
• Availability of relevant clinicopathologic data.
• Availability of survival or follow-up information when applicable.
• Age 18 years or older at diagnosis or tissue collection.

You may not qualify if…

• Insufficient tissue quantity or quality for molecular profiling.
• Inadequate DNA or RNA quality for sequencing or molecular assay preparation.
• Missing essential clinicopathologic information required for analysis.
• Non-appendiceal primary tumor or metastatic tumor to the appendix from another primary site.
• Patients who do not meet institutional review board or consent requirements, if applicable.

Where it is running

• City of Hope Medical Center — Durate, California, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.