Effect of Liposomal Bupivacaine and Bupivacaine Hydrochloride for Superior Trunk Block of the Interscalene Brachial Plexus on Postoperative Diaphragmatic Function and Analgesia
Enrolling by invitation · Not applicable
Conditions studied: Proximal Humerus Surgery, Rotator Cuff Surgery, Shoulder Arthroplasty, Shoulder Arthroscopy
In brief
To compare the effects of 1.33% liposomal bupivacaine versus 0.375% bupivacaine hydrochloride for superior trunk block of the interscalene brachial plexus on postoperative diaphragmatic function and analgesic efficacy in shoulder surgery.
Key facts
- Study ID
- NCT07587203
- Run by
- Nanjing First Hospital, Nanjing Medical University
- People needed
- 184
- Starts
- 2026-06-01
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-06-16
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients scheduled for elective unilateral proximal humerus surgery, rotator cuff surgery, shoulder arthroplasty, or shoulder arthroscopy;
- Visible diaphragmatic movement on the surgical side under ultrasound before anesthesia;
- Patient provides informed consent;
- Age 18-80 years, any gender;
- ASA physical status I-III;
- 18 kg/m² ≤ BMI ≤ 30 kg/m².
You may not qualify if…
- Coagulopathy;
- Allergy to local anesthetics;
- Infection at the puncture site;
- History of chronic pain or opioid use;
- Severe respiratory disease;
- Pregnancy;
- Diabetes and peripheral neuropathy;
- Inability to understand assessment scales.
Where it is running
- Nanjing First Hospital — Nanjing, Jiangsu, China
- Nanjing Gaochun People's Hospital — Nanjing, Jiangsu, China
- The First Affiliated Hospital of Soochow University — Suzhou, Jiangsu, China
Full record on ClinicalTrials.gov
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