Vascular Endothelial Inflammation and Health Status In INOCA (VISION-INOCA)

Starting soon

Conditions studied: Ischemia and Non-obstructive Coronary Arteries

In brief

The purpose of this study is to evaluate coronary artery and peripheral vein vascular endothelial profiles in patients with ischemia with non-obstructive coronary arteries (INOCA) who undergo coronary function testing (CFT). The aims are: (1) Evaluate coronary artery endothelial profiles and associations with coronary microvascular dysfunction (CMD) in INOCA. (2) Assess brachial vein endothelial cell profiles in patients with INOCA and associations with CMD, and (3) Characterize relationships between endothelial signatures and anginal symptoms, functional status, and physical activity at baseline and 1-year follow-up.

Key facts

Study ID: NCT07586241
Run by: NYU Langone Health
People needed: 250
Starts: 2026-05-01
Expected to finish: 2031-03-01
Last updated by the study team: 2026-05-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adult age ≥18 years referred for clinically indicated coronary angiography
Chronic coronary disease or potentially ischemic symptoms as the indication for coronary angiography
Possible or suspected ischemia with non-obstructive epicardial coronary arteries (INOCA)

You may not qualify if…

Clinical (Pre-Cath) Exclusion criteria:
Anemia (hemoglobin <9 mg/dl)
Severe valvular heart disease
Acute myocardial infarction within 30 days
Severe valvular heart disease
New York Heart Association (NYHA) Functional Class III or IV heart failure
Hypertrophic obstructive cardiomyopathy or severe left ventricular hypertrophy
Pregnancy (because of potential exercise/activity limitations and symptom changes)

Where it is running

NYU Langone Health — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.