Comparison of Hemodynamic Responses During Anesthesia Induction Using Eleveld and Schnider

Recruiting now

Conditions studied: Spinal (Fusion) Surgery, Total Intravenous Anesthesia, Target Controlled Infusion of Propofol, Anesthesia Depth Monitoring, BIS-EEG

In brief

This randomized prospective study aims to compare the effects of two target-controlled infusion models, the Schnider and Eleveld models, on anesthetic depth and hemodynamic responses during anesthesia induction in adult patients undergoing spinal surgery. Patients scheduled for spinal surgery will be randomized into either the Schnider or Eleveld group. Before induction, standard monitoring will be applied, including electrocardiography, peripheral oxygen saturation, invasive arterial blood pressure monitoring, heart rate monitoring, and bispectral index monitoring. Anesthesia induction will be performed with fentanyl 2 mcg/kg, rocuronium 0.6 mg/kg, and propofol administered by target-controlled infusion with an effect-site target concentration of 3 mcg/mL according to the allocated pharmacokinetic model. Hemodynamic parameters and bispectral index values will be recorded before induction and at the 1st, 3rd, 5th, and 10th minutes after induction. Additional parameters, including time to BIS below 40, time to delta activity, burst suppression duration, total propofol dose during the first 5 minutes, need for additional propofol, hemodynamic response to intubation, vasopressor requirement within the first 10 minutes, and use of esmolol, will also be documented. The primary aim is to evaluate whether the Schnider and Eleveld models differ in terms of induction-related hemodynamic stability and anesthetic depth during the early induction period.

Key facts

Study ID

NCT07586189

Run by

Istanbul University

People needed

50

Starts

2026-05-18

Expected to finish

2026-08-30

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients scheduled for elective spinal surgery under general anesthesia
• Patients who will undergo surgery at the Neurosurgery Department of Istanbul University, Istanbul Faculty of Medicine
• Patients aged 18 years or older
• Patients who provide written informed consent to participate in the study

You may not qualify if…

• Patients with uncontrolled hypertension
• Patients with uncontrolled diabetes mellitus
• Patients younger than 18 years of age
• Patients who do not provide informed consent to participate in the study

Where it is running

• Istanbul University — Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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