Effect of Laparoscopic Splenectomy on Renal Function in Cirrhotic Patients With Hypersplenism (2-Year Follow-Up)

Starting soon

Conditions studied: Cirrhosis, Splenectomy; Status, Hypersplenism, Kidney Function Issue

In brief

Patients with liver cirrhosis often have impaired or at-risk kidney function due to the close link between liver and kidney (hepatorenal syndrome). Laparoscopic splenectomy is commonly used to treat splenomegaly and hypersplenism in these patients, but its impact on kidney function over 2 years is unclear. This study will follow patients undergoing laparoscopic splenectomy to measure changes in kidney function before and after surgery, identify risk factors for kidney damage and whether laparoscopic splenectomy can improve kidney function in the long term, and help improve care to protect kidney function in cirrhotic patients .

Key facts

Study ID

NCT07585773

Run by

Northern Jiangsu People's Hospital

People needed

30

Starts

2026-05-01

Expected to finish

2029-02-28

Last updated by the study team

2026-05-18

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed diagnosis of liver cirrhosis (clinical, laboratory, imaging)
• Splenomegaly and hypersplenism
• No history of portal hypertension bleeding (esophageal and gastric variceal bleeding )
• Age 18-80 years, male or female
• Child-Pugh Class A or B liver function
• No history of primary renal disease or acute kidney injury (AKI)
• Signed written informed consent
• Ability to complete 24-month follow-up

You may not qualify if…

• Child-Pugh Class C liver cirrhosis
• Primary renal diseases (glomerulonephritis, polycystic kidney disease, chronic pyelonephritis, etc.)
• Previous abdominal surgery precluding safe laparoscopic splenectomy
• Severe cardiac, pulmonary, cerebrovascular dysfunction; malignant tumors; primary hematological disorders
• Cirrhotic complications (portal hypertension bleeding, hepatic encephalopathy, refractory ascites) within 1 month before surgery
• Pregnancy or lactation
• Poor compliance, inability to complete follow-up

Where it is running

• Clinical Medical College of Yangzhou University — Yangzhou, Jiangsu, China

Full record on ClinicalTrials.gov

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