Coronary Artery Disease Screening in Patients With Chronic Kidney Disease
Starting soon
Conditions studied: Chronic Kidney Disease (CKD), Coronary Artery Disease (CAD)
In brief
Patients with chronic kidney disease (CKD) have a markedly increased cardiovascular risk, with coronary artery disease being a leading cause of morbidity and mortality. Conventional cardiovascular risk scores and non-invasive diagnostic tests have limited accuracy in this population, partly due to atypical symptoms and frequent structural heart disease. Coronary flow reserve (CFR) is a key marker of coronary microvascular dysfunction and has strong prognostic value, but its assessment is usually limited to invasive techniques. Recent advances in cadmium-zinc-telluride single-photon emission computed tomography (CZT-SPECT) allow non-invasive measurement of CFR. The EVACKD study aims to evaluate the prognostic value of CFR assessed by CZT-SPECT in patients with CKD for predicting major adverse cardiovascular events over a 2-year follow-up.
Key facts
- Study ID
- NCT07585695
- Run by
- University Hospital, Grenoble
- People needed
- 283
- Starts
- 2026-06-01
- Expected to finish
- 2028-01-31
- Last updated by the study team
- 2026-05-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female patients aged over 18 years
- Affiliated with the French social security system
- Patients at renal risk based on albuminuria (Alb) and glomerular filtration rate (GFR < 30 mL/min/1.73 m², or GFR < 45 mL/min/1.73 m² with albuminuria > 30 mg/g, or GFR < 60 mL/min/1.73 m² with albuminuria > 300 mg/g)
- Patients undergoing, independently of the research and according to the clinician's decision as part of standard care, CZT-SPECT myocardial perfusion imaging with coronary flow reserve measurement for cardiovascular risk assessment
- Having expressed no objection to participation in this study
You may not qualify if…
- Legally protected adult (Article L1121-8 of the French Public Health Code)
- Person deprived of liberty (Article L1121-8 of the French Public Health Code)
- Pregnant woman
- Patient who has undergone a normal coronary exploration within the past year
Where it is running
- CHU Grenoble Alpes — La Tronche, France, France
Full record on ClinicalTrials.gov
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