Regenerative Endodontics in Mature Necrotic Teeth

Starting soon · Not applicable

Conditions studied: Necrotic Teeth With Chronic Apical Periodontitis

In brief

The goal of this clinical trial is to learn if nanochitosan can achieve regeneration in mature necrotic teeth. It will also provide data about the healing potential \& postoperative pain after using different irrigation protocols. The main question it aims to answer are: Does nanochitosan can demonstrate clinically successful outcome, minimize postoperative pain \& flare ups? What is the regenerative potential of mature necrotic teeth with chronic apical periodontitis? Is regeneration an alternative treatment modality for mature necrotic teeth with apical periodontitis? Researcher will compare the regenerative potential \& postoperative pain after using 2.5% NaOCl+ 17% EDTA, 1% nanochitosan \& 1% nanochitosan+17% EDTA to see if 1% nanochitosan alone or when used with 17% EDTA can enhance regeneration. Participants' root canals will be: Divided into 3 groups \&irrigated thoroughly by the different irrigation protocols (2.5% NaOCl+ 17% EDTA, 1% nanochitosan \& 1% nanochitosan+ 17% EDTA) Regenerative procedures will be done Clinical sensibility test \& radiographic changes will be evaluated at 6\&12 months follow up periods Detection of inflammatory mediators from GCF at 6 months follow up periods to be compared with its preoperative levels as a predictor for success or failure Assessment of postoperative pain using Numerical Rating Scale at 6, 12, 24 hours then daily for 7 days

Key facts

Study ID

NCT07584928

Run by

Suez Canal University

People needed

60

Starts

2026-08-01

Expected to finish

2027-12-01

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• medically compromised patients, systemic conditions e.g. uncontrolled diabetes or those on immunosuppressive drugs.
• pregnant females
• patients with generalized chronic periodontitis, mobility, and deep pockets
• non-restorable teeth or teeth with open apices
• teeth where post is needed to be restored or with previous root canal therapy
• teeth with developmental anomalies, external and internal resorption

Where it is running

• Suez Canal University — Ismailia, Egypt

Full record on ClinicalTrials.gov

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