A 2×2 Factorial Randomized Controlled Trial for ERCP

Starting soon · Not applicable

Conditions studied: Biliary and Pancreatic Diseases, Endoscopic Retrograde Cholangiopancreatography (ERCP)

In brief

To investigate the effects of propofol vs. cyclopropofol and sufentanil vs. esketamine on intraoperative hypoxemia and hypotension in elderly patients undergoing ERCP, as well as the interaction between these two factors.

Key facts

Study ID

NCT07584902

Run by

Gang Chen

People needed

236

Starts

2026-04-27

Expected to finish

2026-10-31

Last updated by the study team

2026-05-13

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 60 years old.
• ASA II-III level.
• BMI<30kg/m2.
• Patients who require elective therapeutic ERCP.
• Voluntarily participate in this study and sign an informed consent form. If the subject is unable to read and sign the informed consent form due to reasons such as lack of capacity, their guardian needs to act as a proxy for the informed process and sign the informed consent form. If the subject lacks the ability to read the informed consent form (such as illiterate subjects), a witness is required to witness the informed process and sign the informed consent form.

You may not qualify if…

• Previous anatomical changes in the gastrointestinal tract, delayed gastric emptying, and gastric outlet obstruction.
• Coagulation dysfunction or tendency towards nosebleeds.
• Combined severe heart disease (coronary heart disease, myocardial infarction, congestive heart failure, left ventricular ejection fraction<40%, tachyarrhythmia)
• Have a history of allergies to relevant anesthetic drugs in the past.
• Severe pulmonary diseases (severe asthma attacks, respiratory failure, severe chronic obstructive pulmonary disease, severe interstitial lung disease, large pleural effusion, severe pulmonary arterial hypertension, etc.).
• Existing upper respiratory tract infection (within one week).
• Uncontrolled severe hypertension.
• Patients with increased intracranial pressure; Cerebral hemorrhage, intracranial space occupying lesions, acute phase of traumatic brain injury.
• Glaucoma and significant increase in intraocular pressure.
• Untreated or inadequately treated patients with hyperthyroidism.
• Serious liver and kidney diseases.
• Known neurological and psychiatric disorders (Parkinson's disease, epilepsy, or schizophrenia).
• Difficult airway: The anesthesiologist assessed the presence of difficult airway before surgery.
• Vulnerable groups other than the elderly/illiterate, including those with mental illness, cognitive impairment, critically ill patients, pregnant women, etc.

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.