Efficacy and Safety of Overnight Occlusive HA35 Gel for Facial Aesthetic Improvement

Starting soon · Not applicable

Conditions studied: Facial Subcutaneous Fat, Facial Erythema, Skin Dullness, Nasal Alar Pore Enlargement, Facial Aesthetic Improvement

In brief

This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of overnight occlusive topical application of 10% high-concentration 35 kDa hyaluronan (HA35) gel for facial aesthetic improvement. Eligible participants will receive overnight occlusive application once every 2 days for a total of 5 treatments over 10 days. The primary objectives are to assess changes in facial subcutaneous fat appearance, inflammatory erythema, skin radiance, and nasal alar pore enlargement after 1 and 5 applications. Safety and local tolerability will be evaluated throughout the study period. This is a minimal-risk, non-pharmacological, non-invasive aesthetic intervention.

Key facts

Study ID

NCT07584811

Run by

Nakhia Impex LLC

People needed

30

Starts

2026-05-01

Expected to finish

2026-07-20

Last updated by the study team

2026-05-13

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-60 years, male or female
• Seeking non-invasive improvement of facial appearance
• Presenting with at least one of: facial subcutaneous fat accumulation, facial erythema, skin dullness, nasal alar pore enlargement
• Baseline NRS score ≥2 for at least one target parameter
• Ability to complete self-assessments
• Signed written informed consent

You may not qualify if…

• Facial aesthetic treatments (injection, laser, fat reduction, peeling) within 2 weeks
• Active facial dermatitis, infection, or open wounds
• Known hypersensitivity to hyaluronan or gel components
• Pregnant or lactating women
• Severe systemic disease or uncontrolled medical condition

Full record on ClinicalTrials.gov

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