Homeostatic Regulation of Sleep in Short Sleepers

Starting soon · Not applicable

Conditions studied: Short Sleepers, Normal Sleepers, Idiopathic Hypersomnia Patients

In brief

This single-center study targets adults with distinct sleep profiles, divided into three categories: natural short sleepers, characterized by a reduced nocturnal sleep duration; subjects with idiopathic hypersomnia (IH) followed at the Sleep Disorders Unit of CHU Gui de Chauliac, with excessive daytime sleepiness; and control normal sleepers, with standard sleep duration and no specific complaints. The aim of this study is to analyze the mechanisms of slow-wave regulation during sleep according to sleep phenotype (normal, short, and long sleepers/idiopathic hypersomnia) by examining the decay of EEG spectral power in the delta band over central regions during the first night of continuous 32-hour recording.

Key facts

Study ID

NCT07584538

Run by

University Hospital, Montpellier

People needed

75

Starts

2026-04-01

Expected to finish

2028-04-01

Last updated by the study team

2026-05-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Be aged ≥ 18 years
• Be affiliated with a social security system
• Be able to understand the nature, purpose, and methodology of the study and agree to cooperate during clinical and polysomnographic assessments
• Be fluent in French (speaking and writing)
• Have provided written informed consent
• Sleep duration:
• Short sleepers:
• Weekday sleep duration ≤ 6 hours, with no significant increase at the weekend (weekend sleep duration ≤ 7 hours) and no complaints of daytime sleepiness (ESS <10).
• Normal sleepers: Weekday sleep duration of between 7 and 8 hours, with weekend sleep duration generally similar or slightly longer (between 7 and 9 hours), reflecting a normal sleep duration without restriction or significant catch-up sleep, and with no complaints of daytime sleepiness (ESS <10).
• HI subjects, with increased sleep duration: Increased sleep need, with a reported sleep duration of ≥ 10 hours per night and > 11 hours over a 24-hour period; increased sleep duration associated with excessive daytime sleepiness not explained by another sleep disorder.
• No other sleep disorders
• Apnoea-hypopnoea index (AHI) ≤ 15/h
• Periodic limb movement index ≤ 15/h

You may not qualify if…

• Pre-existing sleep disorders
• Use of medication that affects sleep (such as sedatives, antidepressants, and insomnia medication);
• Use of substances that disrupt sleep or reduce fatigue
• Serious psychiatric disorders
• Pregnancy or breastfeeding
• Persons deprived of their liberty (by court order or administrative decision)

Where it is running

• Gui de Chauliac - CHU Montpellier — Montpellier, France

Full record on ClinicalTrials.gov

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