VABu Conditioning in Elderly AML HSCT

Recruiting now · Phase 2/Phase 3

Conditions studied: Allogeneic Hematopoietic Stem Cell Transplantation Recipient, Acute Myeloid Leukemia (AML)

In brief

This is an open-label, multi-center, single-arm clinical study evaluating the efficacy and safety of the VABu conditioning regimen in elderly patients (≥60 years) with acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation (HSCT). The VABu regimen consists of Venetoclax, Azacitidine, Semustine, Cytarabine, and Busulfan. All enrolled participants will receive the VABu regimen as conditioning therapy prior to HSCT. The study aims to enroll 20 participants from multiple centers in China. The primary objectives are to evaluate the overall response rate, cumulative relapse rate, overall survival, graft-versus-host disease (GVHD)-free relapse-free survival (GRFS), non-relapse mortality (NRM), incidence of acute and chronic GVHD, and reactivation rates of cytomegalovirus (CMV) and Epstein-Barr virus (EBV). Safety outcomes include treatment-related toxicities, such as bone marrow suppression, infection, and organ dysfunction.

Key facts

Study ID

NCT07583888

Run by

The First Affiliated Hospital of Soochow University

People needed

20

Starts

2026-05-07

Expected to finish

2027-08-15

Last updated by the study team

2026-05-14

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 60 years.
• Confirmed diagnosis of acute myeloid leukemia (AML) according to WHO classification, with intermediate or high-risk prognosis.
• Previous response to Venetoclax-based therapy.
• Planned to undergo allogeneic hematopoietic stem cell transplantation (HSCT).
• Donor availability: Related donor matched at least 5/10 at HLA-A, -B, -C, -DQB1, and -DRB1; OR unrelated donor matched at least 8/10 at the same loci.
• Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) score ≤ 4.
• ECOG performance status 0-2.
• Adequate organ function as defined by: Creatinine ≤ 1.5 × ULN or creatinine clearance ≥ 45 mL/min (Cockcroft-Gault formula or 24-hour urine collection)； AST ≤ 3.0 × ULN and ALT ≤ 3.0 × ULN； Total bilirubin ≤ 1.5 × ULN； Left ventricular ejection fraction (LVEF) > 50%； Baseline oxygen saturation > 92%； DLCO ≥ 40% and FEV1 ≥ 50%；
• Ability to understand and provide written informed consent.

You may not qualify if…

• Age < 60 years.
• Poor response to prior Venetoclax-based therapy.
• Unstable systemic disease (unstable angina, myocardial infarction, cerebrovascular accident within 3 months; NYHA Class III-IV heart failure; severe arrhythmia; pulmonary hypertension).
• Active uncontrolled infection or active bleeding in vital organs.
• CNS symptoms grade ≥ 2 requiring treatment.
• Major organ surgery within 6 weeks.
• History of malignant disease other than AML within 5 years.
• History of thrombosis, embolism, or cerebral hemorrhage within 1 year.
• ECOG performance status > 2.
• HCT-CI score > 4.
• Organ failure meeting specified criteria.
• Known HIV, active HBV, or active HCV infection.
• History of autoimmune disease requiring systemic immunosuppressive therapy.
• Pregnancy, breastfeeding, or unwillingness to use effective contraception in patients of childbearing potential.
• Drug abuse or chronic alcoholism.
• Psychiatric disorder or other condition compromising informed consent or compliance.
• Any other condition making the patient unsuitable for study participation in the investigator's judgment.

Where it is running

• The First Affiliated Hospital of Soochow University — Suzhou, Jiangsu, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.